CAJ | 학술논문

胃转流术是目前2型糖尿病外科治疗的主流术式之一,但其治疗2型糖尿病的相关机制并不完全清楚.现有的相关研究表明,胃转流术对2型糖尿病的治疗作用可能通过如下机制:摄入受限和吸收不良、胰岛素抵抗的改善和胰岛β细胞功能的恢复、胃肠道激素水平的变化等.此外,脂肪因子以及血清胆汁酸水平的变化也可能发挥了一定作用.下一步的研究需要进一步明确胃转流术对于机体神经内分泌系统的影响机制,并探讨胃转流术消化道重建方式对于相关激素的影响情况.
위전류술시목전2형당뇨병외과치료적주류술식지일,단기치료2형당뇨병적상관궤제병불완전청초.현유적상관연구표명,위전류술대2형당뇨병적치료작용가능통과여하궤제:섭입수한화흡수불량、이도소저항적개선화이도β세포공능적회복、위장도격소수평적변화등.차외,지방인자이급혈청담즙산수평적변화야가능발휘료일정작용.하일보적연구수요진일보명학위전류술대우궤체신경내분비계통적영향궤제,병탐토위전류술소화도중건방식대우상관격소적영향정황.
Roux-en-Y gastric bypass (RYGB) is a classic procedure for the treatment of type 2 diabetes mellitus (T2DM),but it remains unclear why this procedure works.There might be several mechanisms that RYGB works through to treat T2DM,including calorie restriction and malabsorption,improvement of insulin resistance and β-cell functions,and altered secretion of gastrointestinal hormones.Altered levels of adipokines and serum bile acids might also play a role after RYGB.Future researches should concentrate on the exact mechanism of the altered hormone levels after RYGB,and whether different methods of gastrointestinal tract reconstruction could lead to various hormone levels.