实用肿瘤学杂志
實用腫瘤學雜誌
실용종류학잡지
JOURNAL OF PRACTICAL ONCOLOGY
2013年
6期
573-576
,共4页
姜寰宇(综述)%孙冀(审校)
薑寰宇(綜述)%孫冀(審校)
강환우(종술)%손기(심교)
喉癌%分子靶向治疗%环氧合酶-2%哺乳动物雷帕霉素靶蛋白%诱导型一氧化氮合成酶
喉癌%分子靶嚮治療%環氧閤酶-2%哺乳動物雷帕黴素靶蛋白%誘導型一氧化氮閤成酶
후암%분자파향치료%배양합매-2%포유동물뢰파매소파단백%유도형일양화담합성매
Laryngeal carcinoma%Molecular targeted therapy%COX-2%mTOR%iNOS
近年来,手术及放、化疗在喉癌治疗方面取得了一定进步,但是Ⅲ、Ⅳ期喉癌预后仍不乐观,所以需要新的治疗手段来提高喉癌的治疗效果。癌症的分子靶向治疗很有前景。本文对EGFR,VEGF,COX-2,mTOR,Nm23-H1,iNOS各靶点与喉癌之间的关系,以及相关抑制剂对喉癌治疗的研究进展做一综述。
近年來,手術及放、化療在喉癌治療方麵取得瞭一定進步,但是Ⅲ、Ⅳ期喉癌預後仍不樂觀,所以需要新的治療手段來提高喉癌的治療效果。癌癥的分子靶嚮治療很有前景。本文對EGFR,VEGF,COX-2,mTOR,Nm23-H1,iNOS各靶點與喉癌之間的關繫,以及相關抑製劑對喉癌治療的研究進展做一綜述。
근년래,수술급방、화료재후암치료방면취득료일정진보,단시Ⅲ、Ⅳ기후암예후잉불악관,소이수요신적치료수단래제고후암적치료효과。암증적분자파향치료흔유전경。본문대EGFR,VEGF,COX-2,mTOR,Nm23-H1,iNOS각파점여후암지간적관계,이급상관억제제대후암치료적연구진전주일종술。
Despite recent advances in surgical techniques and radiotherapy and chemotherapy ,the prog-nosis of laryngeal carcinoma is still poor ,especially patients with in the stage ⅢandⅣ.Hence,there needs a no-vel therapy to improve the treatment of laryngeal carcinoma .Molecular targeted therapy represents an exciting field in the treatment of cancer .This review focuses on the relationship between the laryngeal carcinoma and some promising targets,including EGFR,VEGF,COX-2,mTOR,Nm23-H1 and iNOS,and related inhibitors in la-ryngeal carcinoma research .