CAJ | 학술논문

上皮-间质转化（ Epithelial-mesenchymal transition ，EMT）与恶性肿瘤的侵袭及转移有着密切的关系，是目前研究恶性肿瘤侵袭及转移的热点。有大量研究表明在多种恶性肿瘤如乳腺癌、卵巢癌和非小细胞肺癌的侵袭与转移过程中都有上皮-间质转化现象，并阐述上皮-间质转化的信号通路及其蛋白分子。本文对上皮-间质转化在非小细胞肺癌侵袭与转移的研究成果做一综述。
상피-간질전화（ Epithelial-mesenchymal transition ，EMT）여악성종류적침습급전이유착밀절적관계，시목전연구악성종류침습급전이적열점。유대량연구표명재다충악성종류여유선암、란소암화비소세포폐암적침습여전이과정중도유상피-간질전화현상，병천술상피-간질전화적신호통로급기단백분자。본문대상피-간질전화재비소세포폐암침습여전이적연구성과주일종술。
Epithelial-mesenchymal transition is closely related with invasion and metastasis of malig-nant tumor and is focused on invasion and metastasis in malignant tumor in recent years .Many researches dermon-strate that epithelial-mesenchymal transition is involved in invasion and metastasis of several malignant tumors , such as breast cancer ,ovary cancer and non -small cell lung cancer .The relevant signal pathways and molecular proteins are also studied .Research progress of epithelial -mesenchymal transition in non -small cell lung cancer for invasion and metastasis is reviewed in this article .