CAJ | 학술논문

上皮-间充质细胞转换（ epithelial-mesenchymal transition ，EMT）是一个动态的、可逆的过程，使细胞从鹅卵石状的上皮表型转向细长的间充质表型。受微环境和很多因素的诱导，EMT参与胚胎发育、慢性炎症、伤口愈合及肿瘤侵袭转移过程。细胞经历EMT后具有多种生物学特性，包括迁移、侵袭、被诱导成干细胞、防止凋亡、防止衰老及抑制免疫等，在肿瘤的转移、复发和耐药中起着关键作用。弄清EMT在口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）中的作用机制，有助于了解OSCC发展的生物学行为，以发现新的生物标志物用于OSCC患者的诊断、靶向治疗和预后判定。
상피-간충질세포전환（ epithelial-mesenchymal transition ，EMT）시일개동태적、가역적과정，사세포종아란석상적상피표형전향세장적간충질표형。수미배경화흔다인소적유도，EMT삼여배태발육、만성염증、상구유합급종류침습전이과정。세포경력EMT후구유다충생물학특성，포괄천이、침습、피유도성간세포、방지조망、방지쇠로급억제면역등，재종류적전이、복발화내약중기착관건작용。롱청EMT재구강린상세포암（oral squamous cell carcinoma，OSCC）중적작용궤제，유조우료해OSCC발전적생물학행위，이발현신적생물표지물용우OSCC환자적진단、파향치료화예후판정。
Epithelial mesenchymal transition ( EMT) is a dynamic and reversible process ,it makes the cells from the cobble-stone like epithelial phenotype to a slender mesenchymal phenotype .Induced by the microenvironment and many factors ,EMT involve in embryonic development ,inflammation,wound healing and tumor invasion and metastasis process .After undergoing EMT ,cells have vari-ous biological characteristics , including migration, invasion, being induced into stem cells , preventing apoptosis , preventing aging , suppressing immune , and playing a key role in tumor metastasis , re-currence and resistance .To study the mechanism of EMT in oral squa-mous cell carcinoma ( OSCC) is useful for understanding the biological behavior of OSCC development and discovering new biomarkers for the diagnosis ,the targeted therapy and the prognosis of OSCC .