CAJ | 학술논문

目的观察抗炎因子白细胞介素-10(IL-l0)在突出及脱出型腰椎间盘组织中的含量,并探讨其与临床相关性.方法收集30例单节段椎间盘突出症患者,术前由一名受培训的医师进行详细病史询问,明确病程长短,对术前临床症状均给予JOA(下腰痛JOA评分)评定,术后应用酶联免疫吸附测定法(ELISA)测定椎间盘组织中IL-10的含量.IL-10的含量水平与患者病程进行直线相关性研究.结果脱出型与突出型患者IL-10含量差异无统计学意义(t=0.032,P=0.725)；直线相关性分析:IL-10与JOA评分相关系数:r=-0.377,P=0.040.患者病程与JOA评分相关性分析:r=0.449,P=0.013.结论腰椎间盘突出症患者椎间盘组织可以刺激产生抗炎因子,细胞因子水平与临床密切相关.
목적 관찰항염인자백세포개소-10(IL-l0)재돌출급탈출형요추간반조직중적함량,병탐토기여림상상관성.방법 수집30례단절단추간반돌출증환자,술전유일명수배훈적의사진행상세병사순문,명학병정장단,대술전림상증상균급여JOA(하요통JOA평분)평정,술후응용매련면역흡부측정법(ELISA)측정추간반조직중IL-10적함량.IL-10적함량수평여환자병정진행직선상관성연구.결과 탈출형여돌출형환자IL-10함량차이무통계학의의(t=0.032,P=0.725)；직선상관성분석:IL-10여JOA평분상관계수:r=-0.377,P=0.040.환자병정여JOA평분상관성분석:r=0.449,P=0.013.결론 요추간반돌출증환자추간반조직가이자격산생항염인자,세포인자수평여림상밀절상관.
Objective The expression of anti-inflammatory cytokine interleukin(IL)-10 in protrusion and extrusion tissue of intervertebral disc and its correlation with clinical features.Methods The specimens were from 30 cases of disc herniation in single level.The patients were enquired about the medical histories and evaluated by JOA index preoperation before operation,which were all completed by one trained doctor.The contents of IL-10 in the inter=43vertebral disc were detected by enzyme-linked immunosorbent assay after operation.Results The level of IL-10 had no statistical significance between protrusion and extrusion tissue of intervertebral disc (t =0.032,P =0.725).Patient's JOA index has negative correlation with IL-10(r =-0.377,P =0.040),and positive correlation with Patient's history (r =0.449,P =0.013).Conclusion Protrusion and extrusion tissue of intervertebral disc have abilities of excreting anti-inflammatory cytokine IL-10.The level of cytokine has correlation with patient's clinical features.