CAJ | 학술논문

目的：检测胃腺癌中PTEN、VEGF的表达和Ki67增殖指数的关系，探讨三者在不同临床病理特征中表达的临床意义。方法以84例胃腺癌存档的蜡块组织及患者的临床资料作为研究对象，应用免疫组化方法检测组织中PTEN、VEGF和Ki67的表达，以阳性率为计量指标，分析3种蛋白在肿瘤中表达的意义。结果胃腺癌中不同PTEN表达患者Ki67的表达、不同VEGF表达患者Ki67的表达均有显著性差异（ P均＜0．05），胃腺癌中PTEN的表达与是否侵出肌层、有无癌栓显著相关，VEGF的表达与淋巴结检出数量、分化程度显著相关，Ki67的表达与是否侵出肌层、肿瘤最大径显著相关（P＜0．05）。结论胃腺癌中PTEN和VEGF均与Ki67的表达均具有相关性，三者异常表达均对病变进展有重要促进作用。PTEN抑癌作用、VEGF促癌作用可能与Ki67对增殖作用的调节有关。
목적：검측위선암중PTEN、VEGF적표체화Ki67증식지수적관계，탐토삼자재불동림상병리특정중표체적림상의의。방법이84례위선암존당적사괴조직급환자적림상자료작위연구대상，응용면역조화방법검측조직중PTEN、VEGF화Ki67적표체，이양성솔위계량지표，분석3충단백재종류중표체적의의。결과위선암중불동PTEN표체환자Ki67적표체、불동VEGF표체환자Ki67적표체균유현저성차이（ P균＜0．05），위선암중PTEN적표체여시부침출기층、유무암전현저상관，VEGF적표체여림파결검출수량、분화정도현저상관，Ki67적표체여시부침출기층、종류최대경현저상관（P＜0．05）。결론위선암중PTEN화VEGF균여Ki67적표체균구유상관성，삼자이상표체균대병변진전유중요촉진작용。PTEN억암작용、VEGF촉암작용가능여Ki67대증식작용적조절유관。
Objective It is to detect the expressions of PTEN , VEGF and Ki67, and analyze their clinical significance on different pathological characteristics in gastric adenocarcinoma .Methods 84cases of gastric adenocarcinoma specimens and clinical data were selected to study .The expressions of PTEN , VEGF and Ki67 were detected by immunohistochemistry meth-od.The positive rate expressios of PTEN, VEGF and Ki67 were analyzed in neoplasm.Results There were significant differ-ences in the expression of Ki67 among different PTEN expression or VEGF expression (all P<0.05).The expression of PTEN was correlated with extrusive muscle layer and cancer embolus ( all P<0.05) .The expression of VEGF was correlated with lymph node quantity and differentiated degree (all P<0.05).The expression of Ki67 was correlated with muscle layer invasion and tumor size (all P<0.05).Conclusion There were correlation among the expression of PTEN , VEGF and Ki67. Their abnormal expression can promote the progression of gastric adenocarcinoma .The suppressor tumor function of PTEN and the promotion tumor function of VEGF may be correlated with the regulation of Ki 67 on proliferation .