CAJ | 학술논문

目的：研究多层螺旋CT灌注成像（ MSCTPI）参数对胃癌的诊断价值，以及与肿瘤标志物之间的关联性。方法比较胃癌组与正常组的灌注参数，包括血流量（ BF ）、血容量（BV）、平均通过时间（MTF）、表面通透性（PS）；采用Pearson相关分析方法分析灌注参数值与肿瘤标志物的关系，曲线（ ROC）评估BV、BF、MTF、PS对胃癌的诊断效度。结果胃癌PS值明显高于对照组（ P＜0．05）；在2组间BF差异有统计学意义（ P＜0．05），而BV、MTT差异无统计学意义。 Pearson相关显示PS与AFP、CEA、CA199、CA72-4之间有相关性（ r＝0．58，0．40，0．38，0．77），BV、BF、MTT与CEA、AFP、CA199、CA72-4之间无明显相关性。应用ROC曲线分析BV、BF、 MTT、PS对胃癌的诊断鉴别能力，其曲线下面积分别为0．62，0.64，0．50，0．83。当以PS ＞18．85 mL/（ min·100 g），作为强烈提示胃癌组织的可能性时，其敏感度和特异度分别为0．88和0．67。结论 MSCT灌注成像反映了胃肿瘤组织供血的情况，PS评估胃癌的效度最高，PS＝18．85 mL/（min ·100 mg）可作为判断正常胃壁与胃癌的阈值。部分灌注参数与肿瘤标志物间有相关性。
목적：연구다층라선CT관주성상（ MSCTPI）삼수대위암적진단개치，이급여종류표지물지간적관련성。방법비교위암조여정상조적관주삼수，포괄혈류량（ BF ）、혈용량（BV）、평균통과시간（MTF）、표면통투성（PS）；채용Pearson상관분석방법분석관주삼수치여종류표지물적관계，곡선（ ROC）평고BV、BF、MTF、PS대위암적진단효도。결과위암PS치명현고우대조조（ P＜0．05）；재2조간BF차이유통계학의의（ P＜0．05），이BV、MTT차이무통계학의의。 Pearson상관현시PS여AFP、CEA、CA199、CA72-4지간유상관성（ r＝0．58，0．40，0．38，0．77），BV、BF、MTT여CEA、AFP、CA199、CA72-4지간무명현상관성。응용ROC곡선분석BV、BF、 MTT、PS대위암적진단감별능력，기곡선하면적분별위0．62，0.64，0．50，0．83。당이PS ＞18．85 mL/（ min·100 g），작위강렬제시위암조직적가능성시，기민감도화특이도분별위0．88화0．67。결론 MSCT관주성상반영료위종류조직공혈적정황，PS평고위암적효도최고，PS＝18．85 mL/（min ·100 mg）가작위판단정상위벽여위암적역치。부분관주삼수여종류표지물간유상관성。
Objective It is to investigate the value of the Multislice CT Perfusion imaging ( MSCTPI) parameter in the di-agnosis of gastric cancer , and the correlation with tumor markers .Methods perfusion parameters included the Blood flow ( BF) , Blood volume ( BV) , Mean through time ( MTF) , surface permeability ( PS) of gastric cancer group and normal group of were recorded;the relationship of MSCTPI parameter with the tumor markers were analyzed by Pearson correlation analysis , the diagnosis validity of of BV , BF, MTF, PS on gastric cancer were evaluated by curve ( ROC) .Results PS value of Gastric cancer was significantly higher than that of control group (P<0.05), there was significant difference in BF between the two groups (P<0.05), while was no significant difference in BV and MTT .Pearson correlation analysis showed that there were significant correlation between PS value with AFP , CEA, CA199 and CA72-4 respectively (r=0.58, 0.40, 0.38, 0.77), but was no significant correlation between BV ,BF, MTT with CEA, AFP, CA199, CA72-4.ROC curve analysis application BV, BF, MTT, PS identification ability to the diagnosis of gastric cancer ,the area under curve was 0.62, 0.64 , 0.50 and 0. 83 respectively.When PS>18.85 mL/(100 g? min), as strongly suggest the possibility of gastric cancer tissue ,its sensitivity and specific degree were 0.88 and 0.67respectively.Conclusion MSCTPI can reflect gastric tumor tissue blood supply situa -tion, the evaluated validity of PS on gastric cancer is the highest , PS =18.85 mL/(min? 100 mg) can be used as judgment threshold of normal stomach and gastric cancer .Some have correlation between perfusion parameters and tumor markers .