CAJ | 학술논문

目的：研究RhoC蛋白和基质金属蛋白酶-9（ MMP-9）在翼状胬肉中的表达及二者的相关性，探讨利用RhoC及MMP-9作为标记物评估翼状胬肉生物学特性的可行性。方法应用辣根过氧化物酶标记的链霉卵白素免疫组织化学方法（ S-P法）对45例原发性翼状胬肉和16例正常球结膜组织中的RhoC及MMP-9蛋白进行检测。结果 RhoC及MMP-9蛋白在翼状胬肉组织中的表达均显著高于正常结膜组（P均＜0．05）。 RhoC及MMP-9蛋白表达之间的相关系数r＝0．562，有显著性差异（P＜0．05）。结论检测RhoC及MMP-9在翼状胬肉中的表达，可有效判断患者翼状胬肉的发病及复发情况，以便于早期采取相关治疗措施，减轻患者痛苦及经济负担。
목적：연구RhoC단백화기질금속단백매-9（ MMP-9）재익상노육중적표체급이자적상관성，탐토이용RhoC급MMP-9작위표기물평고익상노육생물학특성적가행성。방법응용랄근과양화물매표기적련매란백소면역조직화학방법（ S-P법）대45례원발성익상노육화16례정상구결막조직중적RhoC급MMP-9단백진행검측。결과 RhoC급MMP-9단백재익상노육조직중적표체균현저고우정상결막조（P균＜0．05）。 RhoC급MMP-9단백표체지간적상관계수r＝0．562，유현저성차이（P＜0．05）。결론검측RhoC급MMP-9재익상노육중적표체，가유효판단환자익상노육적발병급복발정황，이편우조기채취상관치료조시，감경환자통고급경제부담。
Objce tive It is to observe the expression and correlation of RhoC protein and matrix metalloproteinases 9 (MMP 9) in pterygium, and explore the feasibility by using RhoC and MMP -9 as a marker to evaluate pterygium biological characteristics .Methods The expression of RhoC and MMP -9 in 45 cases of primary pterygium and 16 cases of normal con-junctival tissue were detected by horseradish peroxidase labeled chain mildew avidin method of immunohistochemistry ( S-P method).Results RhoC protein and MMP -9 protein expression in the tissue of pterygium were higher than that in normal conjunctival group, there was significant difference (P<0.05).The correlation coefficient between RhoC and MMP -9 pro-tein r=0.562, there is significant difference (P<0.05).Conclusion The expression of RhoC and MMP -9 in pterygium can effectively determine the incidence and recurrence of pterygium , so as to take relevant measures in the early treatment , to alle-viate the suffering and economic burden of patients .