CAJ | 학술논문

局部晚期头颈部鳞癌的治疗往往需要包括手术、放疗、化疗参与的综合治疗，治疗应根据肿瘤原发部位、侵犯范围、患者的身体状况、治疗医生的经验等各项条件而采取个体化的多学科综合治疗。对于可手术切除的头颈部鳞癌，手术±术后放疗(或同期放化疗)仍是其主要的治疗方案，而非手术治疗(放化综合治疗)是另一选择，其目的主要是保留器官和功能。对于不能手术的患者，联合放化疗就成为的唯一选择。近年来发表的TAX323和TAX324研究显示，加用紫杉类、烷化类药物的新型诱导化疗较PF诱导化疗方案，可显著延长患者的生存时间。然而，基于新型诱导化疗的治疗策略同标准的同期联合放化疗相比，是否可进一步提高患者的预后，目前尚无设计良好的临床研究结果支持。本研究将探讨局部晚期头颈部鳞癌非手术治疗策略的临床证据和最新进展。
국부만기두경부린암적치료왕왕수요포괄수술、방료、화료삼여적종합치료，치료응근거종류원발부위、침범범위、환자적신체상황、치료의생적경험등각항조건이채취개체화적다학과종합치료。대우가수술절제적두경부린암，수술±술후방료(혹동기방화료)잉시기주요적치료방안，이비수술치료(방화종합치료)시령일선택，기목적주요시보류기관화공능。대우불능수술적환자，연합방화료취성위적유일선택。근년래발표적TAX323화TAX324연구현시，가용자삼류、완화류약물적신형유도화료교PF유도화료방안，가현저연장환자적생존시간。연이，기우신형유도화료적치료책략동표준적동기연합방화료상비，시부가진일보제고환자적예후，목전상무설계량호적림상연구결과지지。본연구장탐토국부만기두경부린암비수술치료책략적림상증거화최신진전。
Deifnitive treatment for locoregionally advanced squamous cell carcinoma of the head and neck region (HNSCC) is challenging, and usually require multidisciplinary efforts involving surgery, radiotherapy, and chemotherapy. Although surgery followed by radiation or chemoradiation therapy remains the standard treatment for resectable disease, combined chemoradiation therapy provides an effective option with organ spearing potential. In addition, combined chemoradiation therapy is the only treatment option for non-metastatic advanced HNSCC. Recently published results from TAX323 and TAX324, two important randomized clinical trials on the efficacy of induction chemotherapy using docetaxel based regimen, showed that induction chemotherapy using TPF can signiifcantly improve patients’ survival as compared to the conventional PF regimen. However, whether TP or TPF induction chemotherapy should be combined with concurrent chemoradiation and considered as part of the standard treatment regimen remains controversial, and requires support from the results of well-designed randomized clinical trial.