CAJ | 학술논문

目的：探讨急性川崎病患儿血清中IL-21的变化。方法选取60例川崎病患儿，使用双抗体夹心酶联免疫吸附试验方法检测血清中的IL-21水平。选取40例正常同年龄小儿对照。结果急性期川崎病患儿血清IL-21水平明显高于对照组，差异有统计学意义（P＜0.05）；且伴有冠状动脉病变的川崎病患儿IL-21水平较无冠状动脉病变患儿增高,差异有统计学意义（P＜0.05）；急性期川崎病患儿血清IL-21水平与冠状动脉扩张程度存在明显正相关（r=0.497，P＜0.05）。结论 IL-21可能参与了川崎病的发生发展，在川崎病冠状动脉变化过程中起到重要作用，可作为预测川崎病患儿病情严重程度及是否易并发冠状动脉病变的一项指标。
목적：탐토급성천기병환인혈청중IL-21적변화。방법선취60례천기병환인，사용쌍항체협심매련면역흡부시험방법검측혈청중적IL-21수평。선취40례정상동년령소인대조。결과급성기천기병환인혈청IL-21수평명현고우대조조，차이유통계학의의（P＜0.05）；차반유관상동맥병변적천기병환인IL-21수평교무관상동맥병변환인증고,차이유통계학의의（P＜0.05）；급성기천기병환인혈청IL-21수평여관상동맥확장정도존재명현정상관（r=0.497，P＜0.05）。결론 IL-21가능삼여료천기병적발생발전，재천기병관상동맥변화과정중기도중요작용，가작위예측천기병환인병정엄중정도급시부역병발관상동맥병변적일항지표。
Objective To probe the serum IL-21 level in children with acute Kawasaki disease. Methods The level of serum IL-21 from 60 children with acute KD and that in 40 normal children were detected by enzyme-linked immune sorbent assay (ELISA) respectively. Results The level of serum IL-21 in acute KD patients was obviously higher than that in healthy control (P<0.05). In addition,the level of serum IL-21 level in acute KD patients showed positive correlation with the degree of coronary artery dilatation (r=0.497,P<0.05). Conclusion The evident increase of serum IL-21 level in acute KD patients has positive correlation with the degree of coronary artery dilatation,which suggests that IL-21 may play a activity in KD. It takes important part in the development of KD,and is an evident mark to predict the complication occurence of CAL in acute KD patients.