江西医药
江西醫藥
강서의약
JIANGXI MEDICAL JOURNAL
2013年
12期
1102-1104
,共3页
儿童%白血病%免疫表型分型%流式细胞术%江西地区
兒童%白血病%免疫錶型分型%流式細胞術%江西地區
인동%백혈병%면역표형분형%류식세포술%강서지구
Children%Leukemia%Immunophenotype%Flow cytometry%Jiangxi
目的：分析了解江西地区儿童白血病(AL)各免疫亚型分布规律及各亚型在不同年龄段的发生率。方法对376例我院收治的江西地区儿童AL患儿采用CD45/侧散射(SSC)双参数散点图设门方法进行流式细胞术细胞表面及浆内分化抗原分析。结果急性淋巴细胞白血病（ALL）297例，占89.6%，急性髓性白血病（AML）79例，占21.4%；ALL中B系266例，占ALL的89.6%，T系31例、占ALL的10.4%；在B系中以普通型ALL多见，占B系ALL的66.1%；在297例ALL中有65例表达髓系CD13、CD33抗原、在79例中有15例表达淋系 CD19、CD3、CD10抗原；10岁以上组与10岁以下组比较、T 系ALL、APL好发于年龄10岁以上组。结论我院收治的江西地区儿童AL各免疫亚型分布与国内外文献报道大致相近，T系及APL好发大于10岁儿童。
目的：分析瞭解江西地區兒童白血病(AL)各免疫亞型分佈規律及各亞型在不同年齡段的髮生率。方法對376例我院收治的江西地區兒童AL患兒採用CD45/側散射(SSC)雙參數散點圖設門方法進行流式細胞術細胞錶麵及漿內分化抗原分析。結果急性淋巴細胞白血病（ALL）297例，佔89.6%，急性髓性白血病（AML）79例，佔21.4%；ALL中B繫266例，佔ALL的89.6%，T繫31例、佔ALL的10.4%；在B繫中以普通型ALL多見，佔B繫ALL的66.1%；在297例ALL中有65例錶達髓繫CD13、CD33抗原、在79例中有15例錶達淋繫 CD19、CD3、CD10抗原；10歲以上組與10歲以下組比較、T 繫ALL、APL好髮于年齡10歲以上組。結論我院收治的江西地區兒童AL各免疫亞型分佈與國內外文獻報道大緻相近，T繫及APL好髮大于10歲兒童。
목적：분석료해강서지구인동백혈병(AL)각면역아형분포규률급각아형재불동년령단적발생솔。방법대376례아원수치적강서지구인동AL환인채용CD45/측산사(SSC)쌍삼수산점도설문방법진행류식세포술세포표면급장내분화항원분석。결과급성림파세포백혈병（ALL）297례，점89.6%，급성수성백혈병（AML）79례，점21.4%；ALL중B계266례，점ALL적89.6%，T계31례、점ALL적10.4%；재B계중이보통형ALL다견，점B계ALL적66.1%；재297례ALL중유65례표체수계CD13、CD33항원、재79례중유15례표체림계 CD19、CD3、CD10항원；10세이상조여10세이하조비교、T 계ALL、APL호발우년령10세이상조。결론아원수치적강서지구인동AL각면역아형분포여국내외문헌보도대치상근，T계급APL호발대우10세인동。
Objective To investigate the lmmunophenotype distribution rule and the incidence of various subtypes in different age groups of leukemia (AL) children treated in our hospital in Jiangxi. Methods The differentiation antigen in the cell surface and plasma from 376 cases of ALL were assayed by flow cytometry analysis with the method of CD45/ side scatter (SSC) double parameters and scatter spot picture. Results 297 cases were acute lymphoblastic leukemia (ALL) (89.6%),79 cases were acute myeloid leukemia (AML)(21.4%). 266 cases were Acute B-cell lymphoblastic leukemia(B-ALL) 31 cases,accounted for 89.6% of ALL,31 cases are acute T-cell lymphoblastic leukemia(T-ALL),accounted for 10.4%of ALL. Commen B-cell acute lymphoblastic leukemia (C-B-ALL) was the most of the B-ALL,accounted for 66.1% of B-ALL.In the 297 cases of ALL,65 cases expressed myeloid antigen CD13 and CD33,In the 79 cases of AML,15 cases expressed lymphocyte antigen CD19,CD3 and CD10. The in-cidence of T-ALL and acute promyelocytic leukemia (APL)in the group over 10 years old are both higher than that under the age of 10. Conclusion The Immunophenotype distribution of AL children treated in our hospital in Jiangxi is similar to those repoted in the domestic and foreign literatures. Children over 10 years old have a higher incidence of T-ALL and APL.
