中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2013年
4期
31-32
,共2页
2型糖尿病%心律失常%脂联素(APN)%肿瘤坏死因子-a(TNF-a)
2型糖尿病%心律失常%脂聯素(APN)%腫瘤壞死因子-a(TNF-a)
2형당뇨병%심률실상%지련소(APN)%종류배사인자-a(TNF-a)
KType 2 diabetic mellitus%Cardiac arrhythmia%Adiponectin%TNF-a
目的：探讨血清脂联素（APN）与肿瘤坏死因子-a（TNF-a）水平与2型糖尿病（T2DM）及糖尿病心脏病变的关系。方法：经心电图检查，合并心律失常的T2DM患者35例为糖尿病合并心律失常组；心电图正常的45例为糖尿病组；32例正常者为对照组。用放射免疫分析法测定3组空腹空腹血清脂联素及肿瘤坏死因子-a水平。结果：糖尿病合并心律失常组血脂联素水平低于糖尿病组及对照组[分别（11.76±8.04）μg/ml、（18.36±11.15）μg/ml、（21.09±7.75）μg/ml]，差别有统计学意义（p＜0.05，p＜0.01）。糖尿病合并心律失常组及糖尿病组肿瘤坏死因子-a高于对照组[分别为（0.95±0.32）μg/ml、（0.91±0.46）μg/ml、（0.71±0.29）μg/ml]，差别有统计学意义（均p＜0.05）。结论：低脂联素水平与糖尿病心脏病变的发生、发展有关；肿瘤坏死因子-a在糖尿病的发生及糖尿病心脏病的形成中有一定作用。
目的：探討血清脂聯素（APN）與腫瘤壞死因子-a（TNF-a）水平與2型糖尿病（T2DM）及糖尿病心髒病變的關繫。方法：經心電圖檢查，閤併心律失常的T2DM患者35例為糖尿病閤併心律失常組；心電圖正常的45例為糖尿病組；32例正常者為對照組。用放射免疫分析法測定3組空腹空腹血清脂聯素及腫瘤壞死因子-a水平。結果：糖尿病閤併心律失常組血脂聯素水平低于糖尿病組及對照組[分彆（11.76±8.04）μg/ml、（18.36±11.15）μg/ml、（21.09±7.75）μg/ml]，差彆有統計學意義（p＜0.05，p＜0.01）。糖尿病閤併心律失常組及糖尿病組腫瘤壞死因子-a高于對照組[分彆為（0.95±0.32）μg/ml、（0.91±0.46）μg/ml、（0.71±0.29）μg/ml]，差彆有統計學意義（均p＜0.05）。結論：低脂聯素水平與糖尿病心髒病變的髮生、髮展有關；腫瘤壞死因子-a在糖尿病的髮生及糖尿病心髒病的形成中有一定作用。
목적：탐토혈청지련소（APN）여종류배사인자-a（TNF-a）수평여2형당뇨병（T2DM）급당뇨병심장병변적관계。방법：경심전도검사，합병심률실상적T2DM환자35례위당뇨병합병심률실상조；심전도정상적45례위당뇨병조；32례정상자위대조조。용방사면역분석법측정3조공복공복혈청지련소급종류배사인자-a수평。결과：당뇨병합병심률실상조혈지련소수평저우당뇨병조급대조조[분별（11.76±8.04）μg/ml、（18.36±11.15）μg/ml、（21.09±7.75）μg/ml]，차별유통계학의의（p＜0.05，p＜0.01）。당뇨병합병심률실상조급당뇨병조종류배사인자-a고우대조조[분별위（0.95±0.32）μg/ml、（0.91±0.46）μg/ml、（0.71±0.29）μg/ml]，차별유통계학의의（균p＜0.05）。결론：저지련소수평여당뇨병심장병변적발생、발전유관；종류배사인자-a재당뇨병적발생급당뇨병심장병적형성중유일정작용。
Objective To explore the relationship of adiponectin(APN),tumor necrosis factor-alpha (TNF-a) with diabetic arrhythmia.Methods 80 patients with type 2 diabetic mellitus(DM) were divided into DMA group (n=45 ECG showed mormal) 32 healthy people were as control Their serum APN,TNF-a were tested with radioimmunoassay .Results Serum APN level in DMA was lower than that in control and DM group[(11.76±8.04) VS (18.36±11.15) and (21.09±7.75)μg/ml,p<0.01,p<0.05];Serum TNF-a was higher in DMA and DM group than in contro group[(0.95±0.32)and (0.91±0.46) VS (0.71±0.29)μg/ml, p<0.05,p<0.05].Conclusion There was a relation between Hypoadiponectine mia and the occurrence&development of diabetic eardiac disease;The TNF-a may affect the occurrence of type 2 DM and the form of diabetic cardiac arrhythmia.
