CAJ | 학술논문

目的：探讨Girdin蛋白在乳腺癌组织中的表达及其意义。方法采用免疫组化Envision二步法检测128例浸润性乳腺癌、38例导管内癌、30例单纯性导管上皮增生及30例正常乳腺组织中Girdin蛋白的表达情况，并分析其临床病理意义。结果 Girdin蛋白在正常乳腺组织、单纯性导管上皮增生、导管内癌及浸润性乳腺癌中的阳性表达率分别为10.0%、23.3%、42.1%、51.6%，呈逐级上升趋势，差异有统计学意义（P＜0.05）。浸润性乳腺癌组织中Girdin蛋白的表达与TNM分期、淋巴结转移及人表皮生长因子受体2（HER-2）表达明显相关，并与患者的生存时间也明显相关（均P＜0.05）。结论 Girdin蛋白在乳腺癌的发生、演变过程中起重要作用。其表达与患者的生存期密切相关，可作为预测乳腺癌预后的参考指标。
목적：탐토Girdin단백재유선암조직중적표체급기의의。방법채용면역조화Envision이보법검측128례침윤성유선암、38례도관내암、30례단순성도관상피증생급30례정상유선조직중Girdin단백적표체정황，병분석기림상병리의의。결과 Girdin단백재정상유선조직、단순성도관상피증생、도관내암급침윤성유선암중적양성표체솔분별위10.0%、23.3%、42.1%、51.6%，정축급상승추세，차이유통계학의의（P＜0.05）。침윤성유선암조직중Girdin단백적표체여TNM분기、림파결전이급인표피생장인자수체2（HER-2）표체명현상관，병여환자적생존시간야명현상관（균P＜0.05）。결론 Girdin단백재유선암적발생、연변과정중기중요작용。기표체여환자적생존기밀절상관，가작위예측유선암예후적삼고지표。
Objective To investigate the expression of Girdin in breast cancer and its clinicopathological significance. Methods Envision immunohistochemical method was used to assess the expression of Girdin in 128 cases of invasive breast cancer, 38 cases of breast cancer in situ, 30 cases of ductal epithelial simple hyperplasia and 30 normal breast tissue samples. The clinicopathological significance of Girdin expression was evaluated. Results The positive expression of Girdin in normal tis-sues, simple ductal epithelial hyperplasia, breast cancer in situ and invasive breast cancer was 10.0%, 23.3%, 42.1%and 51.6%respectively;there were significant differences among groups (P<0.05). The expression of Girdin in invasive breast cancer was positively correlated with TNM grading, lymph node metastasis and HER- 2 expression;it was negatively correlated with the sur-vival time of patients (al P<0.05). Conclusion The Girdin protein may be involved in the development of breast cancer. The ex-pression of Girdin can be used as a predictor for outcomes of invasive breast cancer.