CAJ | 학술논문

冠状动脉平滑肌细胞膜上存在许多大电导钙离子激活钾（BKCa）通道，在维持细胞正常生理活动中起重要作用。研究发现当细胞膜去极化或/（和）细胞内钙离子增加时，BKCa通道激活，开放增加，钾离子外流，细胞膜超极化，血管舒张。而在高血压、糖尿病、缺氧、心力衰竭和老化等许多病理情况下，BKCa通道功能发生改变，从而影响对血管功能的调节。本文主要综述近年来BK通道在心血管疾病中的研究进展。
관상동맥평활기세포막상존재허다대전도개리자격활갑（BKCa）통도，재유지세포정상생리활동중기중요작용。연구발현당세포막거겁화혹/（화）세포내개리자증가시，BKCa통도격활，개방증가，갑리자외류，세포막초겁화，혈관서장。이재고혈압、당뇨병、결양、심력쇠갈화노화등허다병리정황하，BKCa통도공능발생개변，종이영향대혈관공능적조절。본문주요종술근년래BK통도재심혈관질병중적연구진전。
Large conductance Ca2+-activated K+channels (BKCa channel) are found to be abundantly expressed in the membrane of coronary vascular smooth muscle cells, and play an important role in the maintenance of cellular physiological functions. Evidence shows that cell membrane depolarization and/or increase in intra-cellular Ca2+ activates BKCa channels, then the opening of the channels enables K+efflux, thus finally, membrane hyperpolarization and vasodilation take place. However, the functions of BKCa channels are altered under some pathophysiological conditions, such as hypertension, diabetes mellitus, hypoxia, heart failure, aging and so on. This alteration exerts dramatic impacts on vascular functions. The paper mainly reviewed the recent research progress in BKCa channel in cardiovascular diseases.