CAJ | 학술논문

目的：分析术前放、化疗联合手术治疗老年中晚期食管癌的临床疗效。方法将60例老年食管癌患者随机分为术前放、化疗联合手术治疗组（联合治疗组）和单纯手术组，每组各30例。联合治疗组术前予以辅助放、化疗，放、化疗结束3～5周后行手术切除治疗；单纯手术组仅实施手术治疗。结果联合治疗组总有效率为76．67％，明显优于单纯手术组的30．00％（P＜0．05），且联合治疗组患者术后骨髓抑制、恶心呕吐及放射性食管炎发生率均低于单纯手术组（P＜0．05）。患者总随访率为96．67％，随访结果显示联合治疗组总复发率低于单纯手术组，且除1年局部控制率两组间差异无统计学意义（P ＞0．05）外，联合治疗组的肿瘤局部控制率、生存率均明显优于单纯手术组（P＜0．05）。结论术前辅助放、化疗能提高老年中、晚期食管癌手术疗效，提高肿瘤局部控制率和生存率，减少肿瘤复发和转移。
목적：분석술전방、화료연합수술치료노년중만기식관암적림상료효。방법장60례노년식관암환자수궤분위술전방、화료연합수술치료조（연합치료조）화단순수술조，매조각30례。연합치료조술전여이보조방、화료，방、화료결속3～5주후행수술절제치료；단순수술조부실시수술치료。결과연합치료조총유효솔위76．67％，명현우우단순수술조적30．00％（P＜0．05），차연합치료조환자술후골수억제、악심구토급방사성식관염발생솔균저우단순수술조（P＜0．05）。환자총수방솔위96．67％，수방결과현시연합치료조총복발솔저우단순수술조，차제1년국부공제솔량조간차이무통계학의의（P ＞0．05）외，연합치료조적종류국부공제솔、생존솔균명현우우단순수술조（P＜0．05）。결론술전보조방、화료능제고노년중、만기식관암수술료효，제고종류국부공제솔화생존솔，감소종류복발화전이。
Objective To investigate the clinical curative effect of surgery combined with preoperative chemo -therapy and radiotherapy for treating elderly advanced esophageal cancer .Methods A total of 60 elderly patients with esophageal cancer were randomly divided into the combined therapy group and the simple surgery group ,with 30 cases in each group .The combined therapy group was giren the preoperative assisted radiochemotherapy ,and per-formed the operative resection in 3 - 5 weeks after radiochemotherapy ,while the simple surgery group was treated by surgery alone .Results The overall effective rate in the combined therapy group was 76 .67% ,which was signifi-cantly higher than 30 .00% the simple surgery group(P< 0 .05) ,and the occurrence rates of bone marrow suppres-sion ,nausea ,vomiting and esophagitis in the combined therapy group were lower than those in the simple surgery group (P< 0 .05) .The total follow-up rate was 96 .67% ,and in the combined therapy group ,the total recurrence rate ,local tumor control rate and survival rate were significantly superior to those in the simple occurrence surgery group (P< 0 .05) .Conclusion The assisted preoperatire chemotherapy and radiotherapy could improve the curative effect of surgery for elderly advanced esophageal cancer ,improve the local tumor control rate and the survival rate , and reduce tumor recurrence and tumor metastasis .