CAJ | 학술논문

目的：分析男性泌尿生殖道感染的4种与性传播有关的病原体的分离及治疗情况。方法306例男性泌尿生殖道标本应用免疫层析法检测沙眼衣原体（Ct）抗原，培养法检查淋病奈瑟菌（Ngo）、解脲脲原体（Uu）和人型支原体（Mh）。病原体阳性者按规范疗程治疗后进行复查。结果306例标本中4种病原体的总阳性率为25．49％（78/306），其中 Uu 、Mh 、Ct 、Uu ＋ Mh 、Uu ＋ Ct 以及 Ngo 的阳性率分别为13．40％、0．33％、1．31％、6．21％、1．31％和2．94％。 Uu 和 Mh 药敏试验结果显示，敏感率较高的抗菌药物有强力霉素（92．30％）、美满霉素（90．76％）、交沙霉素（75．38％）和加替沙星（72．31％）。 Uu 和 Mh 感染者用强力霉素治疗2周有效率为73．33％，治疗3周有效率为93．33％。结论 Uu 是男性泌尿生殖道感染最常见的病原体，其次是 Mh 、Ct 和 Ngo 的感染率都比较低。该地区非淋菌性尿道炎的经验治疗首选强力霉素，并且采用3周疗程有效率更高。地方性的支原体耐药性监测分析及治疗效果对比研究对指导临床合理用药意义重大。
목적：분석남성비뇨생식도감염적4충여성전파유관적병원체적분리급치료정황。방법306례남성비뇨생식도표본응용면역층석법검측사안의원체（Ct）항원，배양법검사임병내슬균（Ngo）、해뇨뇨원체（Uu）화인형지원체（Mh）。병원체양성자안규범료정치료후진행복사。결과306례표본중4충병원체적총양성솔위25．49％（78/306），기중 Uu 、Mh 、Ct 、Uu ＋ Mh 、Uu ＋ Ct 이급 Ngo 적양성솔분별위13．40％、0．33％、1．31％、6．21％、1．31％화2．94％。 Uu 화 Mh 약민시험결과현시，민감솔교고적항균약물유강력매소（92．30％）、미만매소（90．76％）、교사매소（75．38％）화가체사성（72．31％）。 Uu 화 Mh 감염자용강력매소치료2주유효솔위73．33％，치료3주유효솔위93．33％。결론 Uu 시남성비뇨생식도감염최상견적병원체，기차시 Mh 、Ct 화 Ngo 적감염솔도비교저。해지구비림균성뇨도염적경험치료수선강력매소，병차채용3주료정유효솔경고。지방성적지원체내약성감측분석급치료효과대비연구대지도림상합리용약의의중대。
Objective To analyse the isolation and treatment situation of 4 kinds of sexually tranmitted patho-gens in male urogenital tract infection .Methods 306 male urogenital tract specimens were detected chlamydia tracho -matis antigen (Ct ) by the immunochromatographic method ,neisseria gonorrhoeae (Ngo ) ,Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh) by the culture method .The cases with positive pathogens were treated by standard treatment course .Then the reexamination was conducted .Results Among 306 specimens ,the total positive rate of 4 kinds of pathogens was 25 .49% (78/306) ,the positive rates of Uu ,Mh ,Ct ,Uu + Mh and Uu + Ct were 3 .40% ,0 .33% ,1 .31% ,6 .21% ,1 .31% and 2 .94% respectively .The drug sensitivity test results of Uu and Mh re-vealed that the higher sensitive antibacterial drugs were doxycyclin (92 .30% ) ,minocin (90 .76% ) ,josanmycin (75 .38% ) and gatifloxacin(72 .31% ) .The efffective rates of 2-week and 3-week doxycycline treatment were 73 .33%and 93 .33% respectively .Conclusion Uu is the most common pathogen in male urogenital tract infection ,followed by Mh .The infection rate of Ct and Ngo is very low .The empirical therapy of non-Ngo urethritis in this area is doxy-cycline as the first choice .Furthermore ,the 3-week course of treatment has higher effective rate .The local drug re-sistance monitoring of mycoplasma and the comparative study of the treatment effects have very important signifi -cance to guide the clinical rational drug use .