中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
5期
1123-1124
,共2页
金俊硕%何淑赛%高英兰%董玉玺%李德旭
金俊碩%何淑賽%高英蘭%董玉璽%李德旭
금준석%하숙새%고영란%동옥새%리덕욱
胰腺导管癌%胰岛%分化
胰腺導管癌%胰島%分化
이선도관암%이도%분화
Pancreatic adenocarcinoma%Islet%Differentiation
目的 观察胰腺导管癌的形态学,探讨胰岛在胰腺导管癌的发生、发展过程中的作用.方法 收集52例胰腺导管癌标本进行形态学研究并标记嗜铬素A (CGA)和细胞角蛋白-7(CK-7)以进行定位、定性研究.结果 34例胰腺导管癌组织中胰岛形态失常,其中11例出现胰岛空泡化及导管样结构,其中7例由胰岛细胞化生的导管样上皮CGA染色减弱、CK-7染色阳性.结论 胰岛转分化为导管样组织是胰腺导管癌的发生、发展过程中重要的组成部分,是胰腺导管癌的细胞来源之一.
目的 觀察胰腺導管癌的形態學,探討胰島在胰腺導管癌的髮生、髮展過程中的作用.方法 收集52例胰腺導管癌標本進行形態學研究併標記嗜鉻素A (CGA)和細胞角蛋白-7(CK-7)以進行定位、定性研究.結果 34例胰腺導管癌組織中胰島形態失常,其中11例齣現胰島空泡化及導管樣結構,其中7例由胰島細胞化生的導管樣上皮CGA染色減弱、CK-7染色暘性.結論 胰島轉分化為導管樣組織是胰腺導管癌的髮生、髮展過程中重要的組成部分,是胰腺導管癌的細胞來源之一.
목적 관찰이선도관암적형태학,탐토이도재이선도관암적발생、발전과정중적작용.방법 수집52례이선도관암표본진행형태학연구병표기기락소A (CGA)화세포각단백-7(CK-7)이진행정위、정성연구.결과 34례이선도관암조직중이도형태실상,기중11례출현이도공포화급도관양결구,기중7례유이도세포화생적도관양상피CGA염색감약、CK-7염색양성.결론 이도전분화위도관양조직시이선도관암적발생、발전과정중중요적조성부분,시이선도관암적세포래원지일.
Objective To identify the relationship between islet and pancreatic adenocarcinoma.Methods Fifty-two cases of pancreatic adenocarcinoma sections were used for morphological analysis,and chromogranin A (CGA) and cytokeratin-7 (CK-7) were detected as immunological markers for islet and duct.Results The deformation of islet was found in 35 of the 52 cases,including vacuolation and tube-like structure in 11,among them 7 cases showed weakened CGA staining in the ductalepithelioid cells by transdifferentiation,and positive CK-7.Conclusion Islet provided precursors of tumor cells and participated in formation of pancreatic adenocarcinoma.
