国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
9期
1285-1287
,共3页
血清同型半耽氛酸%胱抑素C%2型糖尿病合并肾病%诊断指标
血清同型半耽氛痠%胱抑素C%2型糖尿病閤併腎病%診斷指標
혈청동형반탐분산%광억소C%2형당뇨병합병신병%진단지표
Homocysteine%Serum cystatin C%Type 2 diabetes%Diagnostic index
目的 在临床上对2型糖尿病合并肾病患者的血清同型半胱氨酸(Homocysteine,Hcy)水平和胱抑素C (Cystatin C,Cys C)水平进行测定,并探讨两指标在临床诊断中的价值.方法 回顾我院自选2011年6月至2013年6月间在我院进行治疗的184例糖尿病患者的病例.参照患者临床尿清白蛋白(UAER)水平分为糖尿病无肾病组(86例)和糖尿病合并肾病组(98例),并选择90例健康体检者作为对照组.对三组的Hcy、Cys C和UAER的水平进行测定和对比分析.结果 糖尿病合并肾病患者的Hcy、Cys C和UAER水平分别为(22.48±2.42)μmol/L、(2.37±0.92) mg/L和(365.41±62.85) mg/24 h显著性的大于糖尿病无肾病患者(8.13±2.01)μmol/L、(1.01±0.62) rng/L和(36.47±10.26) mg/24 h和健康对照组(7.01±1.46)μmol/L、(0.91±0.59) mg/L和(29.41±8.58) mg/24 h,(P＜0.05).而糖尿病无肾病患者的Hcy、Cys C和UAER水平略大于对照组患者,但两组间差异无统计学意义(P＞0.05).多元线性分析结果表明:糖尿病合并肾病患者的Hcy、Cys C和UAER成正相关性(r=0.281、0.312,P＜ 0.05).结论 Hcy和Cys C可作为临床诊断患者糖尿病状况的有效指标,联合使用能显著提升诊断的准确率.
目的 在臨床上對2型糖尿病閤併腎病患者的血清同型半胱氨痠(Homocysteine,Hcy)水平和胱抑素C (Cystatin C,Cys C)水平進行測定,併探討兩指標在臨床診斷中的價值.方法 迴顧我院自選2011年6月至2013年6月間在我院進行治療的184例糖尿病患者的病例.參照患者臨床尿清白蛋白(UAER)水平分為糖尿病無腎病組(86例)和糖尿病閤併腎病組(98例),併選擇90例健康體檢者作為對照組.對三組的Hcy、Cys C和UAER的水平進行測定和對比分析.結果 糖尿病閤併腎病患者的Hcy、Cys C和UAER水平分彆為(22.48±2.42)μmol/L、(2.37±0.92) mg/L和(365.41±62.85) mg/24 h顯著性的大于糖尿病無腎病患者(8.13±2.01)μmol/L、(1.01±0.62) rng/L和(36.47±10.26) mg/24 h和健康對照組(7.01±1.46)μmol/L、(0.91±0.59) mg/L和(29.41±8.58) mg/24 h,(P＜0.05).而糖尿病無腎病患者的Hcy、Cys C和UAER水平略大于對照組患者,但兩組間差異無統計學意義(P＞0.05).多元線性分析結果錶明:糖尿病閤併腎病患者的Hcy、Cys C和UAER成正相關性(r=0.281、0.312,P＜ 0.05).結論 Hcy和Cys C可作為臨床診斷患者糖尿病狀況的有效指標,聯閤使用能顯著提升診斷的準確率.
목적 재림상상대2형당뇨병합병신병환자적혈청동형반광안산(Homocysteine,Hcy)수평화광억소C (Cystatin C,Cys C)수평진행측정,병탐토량지표재림상진단중적개치.방법 회고아원자선2011년6월지2013년6월간재아원진행치료적184례당뇨병환자적병례.삼조환자림상뇨청백단백(UAER)수평분위당뇨병무신병조(86례)화당뇨병합병신병조(98례),병선택90례건강체검자작위대조조.대삼조적Hcy、Cys C화UAER적수평진행측정화대비분석.결과 당뇨병합병신병환자적Hcy、Cys C화UAER수평분별위(22.48±2.42)μmol/L、(2.37±0.92) mg/L화(365.41±62.85) mg/24 h현저성적대우당뇨병무신병환자(8.13±2.01)μmol/L、(1.01±0.62) rng/L화(36.47±10.26) mg/24 h화건강대조조(7.01±1.46)μmol/L、(0.91±0.59) mg/L화(29.41±8.58) mg/24 h,(P＜0.05).이당뇨병무신병환자적Hcy、Cys C화UAER수평략대우대조조환자,단량조간차이무통계학의의(P＞0.05).다원선성분석결과표명:당뇨병합병신병환자적Hcy、Cys C화UAER성정상관성(r=0.281、0.312,P＜ 0.05).결론 Hcy화Cys C가작위림상진단환자당뇨병상황적유효지표,연합사용능현저제승진단적준학솔.
Objective To investigate the clinical value of determining serum cystatin C and homocysteine contents in patients with type 2 diabetes (DM2) complicated with nephropathy.Methods 184 cases of DM2 patients in our hospital from Jun 2011 to Jun 2013 were retrospectively analyzed.Based on the UAER level,patients were divided into diabetic with nephropathy group (98 cases) and diabetic without nephropathy group (86 cases).And 90 cases of healthy people were selected as control group.Results The levels of serum cystatin C,homocysteine and urine protein in diabetic with nephropathy group were (22.48 ± 2.42) μ mol/L,(2.37 ± 0.92) mg/L,(365.41 ± 62.85) mg/24 h respectively,which were significantly higher than those of diabetic without nephropathy group [(8.13 ± 2.01) μ mol/L,(1.01 ± 0.62) mg/L,(36.47 ± 10.26) mg/24 h] and control group [(7.01 ± 1.46) μ mol/L,(0.91 ± 0.59) mg/L,(29.41 ± 8.58) mg/24 h],P ＜ 0.05.There was no significant difference in levels of serum cystatin C,homocysteine and urine protein between diabetic without nephropathy group and control group (P ＞ 0.05).Multiple linear analysis results showed that the relationship among Hcy,Cys C and UAER was a positive correlation (r=0.281,0.312; P ＜ 0.05).Conclusion The levels of serum cystatin C and homocysteine can be used as sensitive markers for early diagnosis of development of diabetic nephropathy.Their combined use can significantly increase the accurate rate of diagnosis.
