CAJ | 학술논문

目的检测多发性骨髓瘤(MM)患者血清胱抑素C(Cys-C)水平的变化,探讨其对肾损害的早期评估意义.方法选择42例初发MM患者(MM组)和30例健康体检者(对照组),MM组按照国际分期标准(ISS)分期:Ⅰ期9例,Ⅱ期23例,Ⅲ期10例.分别测定其血清Cys-C、肌酐(SCr)及β2-微球蛋白(β2-MG)水平,并比较.结果 MM组血清Cys-C水平高于对照组[(2.34±0.57) mg/L比(0.66 ±0.12) mg/L],且Cys-C水平随ISS分期的升高而升高[Ⅰ,Ⅱ,Ⅲ期分别为(1.77±0.38),(2.11±0.46),(3.14±1.07) mg/L],差异均有统计学意义(P＜0.05).血清Cys-C水平与β2-MG水平以及SCr水平呈正相关(r=0.760,0.694,P＜0.05).结论 MM患者血清Cys-C水平上调,并与肾损害及肿瘤负荷有关;其可作为评价早期肾损害及肿瘤负荷的潜在指标.
목적 검측다발성골수류(MM)환자혈청광억소C(Cys-C)수평적변화,탐토기대신손해적조기평고의의.방법 선택42례초발MM환자(MM조)화30례건강체검자(대조조),MM조안조국제분기표준(ISS)분기:Ⅰ기9례,Ⅱ기23례,Ⅲ기10례.분별측정기혈청Cys-C、기항(SCr)급β2-미구단백(β2-MG)수평,병비교.결과 MM조혈청Cys-C수평고우대조조[(2.34±0.57) mg/L비(0.66 ±0.12) mg/L],차Cys-C수평수ISS분기적승고이승고[Ⅰ,Ⅱ,Ⅲ기분별위(1.77±0.38),(2.11±0.46),(3.14±1.07) mg/L],차이균유통계학의의(P＜0.05).혈청Cys-C수평여β2-MG수평이급SCr수평정정상관(r=0.760,0.694,P＜0.05).결론 MM환자혈청Cys-C수평상조,병여신손해급종류부하유관;기가작위평개조기신손해급종류부하적잠재지표.
Objective According to the level of serum cystatin C (Cys-C)in patients with multiple myeloma (MM),to explore its significance of early assessment to renal damage.Methods To select 42 patients with MM(MM group) and 30 healthy subjects(control group),and measure serum Cys-C,creatinine (SCr) and β2-microglobulin (β2-MG).Results The level of serum Cys-C in MM group was significantly higher than that in control group [(2.34 ± 0.57) mg/L vs.(0.66 ± 0.12) mg/L],which increased with ISS stage[Ⅰ,Ⅱ,Ⅲ stage was(1.77 ± 0.38),(2.11 ± 0.46),(3.14-± 1.07) mg/L](P＜ 0.05).Cys-C and β 2-MG,renal function had a positive correlation (r =0.760,0.694,P ＜ 0.05).Conclusion The increasing of Cys-C in MM patients is related to impaired renal function and tumor burden,which can be used as an early assessment indicators.