CAJ | 학술논문

目的观察补肾降糖方对肥胖2型糖尿病Homa-IR及FFA的影响。方法75例肥胖2型糖尿病患者随机分成两组，其中治疗组45例，对照组30例。所有患者均血糖、血压控制平稳。治疗组在糖尿病常规治疗的基础上，加用自拟补肾降糖方（黄芪24 g、山药18 g、沙苑子15 g、黄精15 g、制大黄9 g、鹿角胶15 g、金银花15 g、川芎18 g、丹参18 g）。水煎200 mL。服用汤药期间1剂/d，服用中药3个月。密切监测血糖。观察两组中医证候、游离脂肪酸（FFA）、胰岛素抵抗指数（Homa-IR）的变化。结果两组在中医证候疗效方面，治疗组明显优于对照组(<0.05)。对照组与治疗前相比Homa-IR、FFA较治疗前有所下降，但无统计学差异（>0.05）。治疗组FFA、Homa-IR与治疗前相比明显下降（<0.05），下降幅度明显优于对照组，具有统计学差异（<0.05）。治疗过程中除了少数的低血糖反应，均未出现其余明显不良反应。结论自拟补肾降糖方能降低肥胖2型糖尿病Homa-IR与FFA，在改善胰岛素抵抗方面中药具有一定的优势，其作用机制可能与降低FFA有关。
목적관찰보신강당방대비반2형당뇨병Homa-IR급FFA적영향。방법75례비반2형당뇨병환자수궤분성량조，기중치료조45례，대조조30례。소유환자균혈당、혈압공제평은。치료조재당뇨병상규치료적기출상，가용자의보신강당방（황기24 g、산약18 g、사원자15 g、황정15 g、제대황9 g、록각효15 g、금은화15 g、천궁18 g、단삼18 g）。수전200 mL。복용탕약기간1제/d，복용중약3개월。밀절감측혈당。관찰량조중의증후、유리지방산（FFA）、이도소저항지수（Homa-IR）적변화。결과량조재중의증후료효방면，치료조명현우우대조조(<0.05)。대조조여치료전상비Homa-IR、FFA교치료전유소하강，단무통계학차이（>0.05）。치료조FFA、Homa-IR여치료전상비명현하강（<0.05），하강폭도명현우우대조조，구유통계학차이（<0.05）。치료과정중제료소수적저혈당반응，균미출현기여명현불량반응。결론자의보신강당방능강저비반2형당뇨병Homa-IR여FFA，재개선이도소저항방면중약구유일정적우세，기작용궤제가능여강저FFA유관。
Objective To observe The Ef ect of Self-made Kindey-tonifying of Chinese Medicine on Homa-IR and FFA in Obesity Diabetes. Methods 75 obesity patients with type 2 diabetes mel itus were divided into two group ramdomly, Treatment group(n=45),control group(n=30). Al of the patients Treatment group were treated with Kindey-tonifying medicine (including Astragalus24g,Yam 18g,semen astragali complanati 15g, rhizoma polygonati 15g, rhubard 9g, Col a Comus Cervi 15g, honeysuckle 15g, Ligusticum wal ichi 18g, salvia miltiorrhiza 18g) boiled to 200ml, once a day, for 3 monthes. To observe the change of Chinese syndrome, Homa-IR,FFA.Results The treatment group could improve the syndrome, which was significantly different from control group ( <0.05).Homa-IR and FFA were reduced after intervention,but Homa-IR and FFA of treatment group was significantly reduced, as compared to control group ( <0.05).Beside of a few hypoglycemia, there was lit le adverse reaction during the research. Conclusion Self-made Kindey-tonifying of Chinese Medical in treating obesity patients with type 2 diabetes mel itus is effective, there are advantage in releasing Chinese syndrome and reducing Homa-IR. The mechanism is probable in reducing FFA.