浙江化工
浙江化工
절강화공
ZHEJIANG CHEMICAL INDUSTRY
2014年
1期
4-6
,共3页
鲍樟水%冯启%夏旭建%郑昀红%孔小林
鮑樟水%馮啟%夏旭建%鄭昀紅%孔小林
포장수%풍계%하욱건%정윤홍%공소림
2,4,5-三氟苯乙酸%氰乙酸乙酯%西他列汀%合成
2,4,5-三氟苯乙痠%氰乙痠乙酯%西他列汀%閤成
2,4,5-삼불분을산%청을산을지%서타렬정%합성
2,4,5-trifluorophenylacetic acid%ethyl cyanoacetate%sitagliptin%synthesis
以1,2,4,5-四氟苯和氰乙酸乙酯为原料,经过取代反应、水解脱羧反应制备得到2,4,5-三氟苯乙酸。该法操作简单、反应路线短、不使用剧毒氰化物,为合成2,4,5-三氟苯乙酸提供了新的途径。
以1,2,4,5-四氟苯和氰乙痠乙酯為原料,經過取代反應、水解脫羧反應製備得到2,4,5-三氟苯乙痠。該法操作簡單、反應路線短、不使用劇毒氰化物,為閤成2,4,5-三氟苯乙痠提供瞭新的途徑。
이1,2,4,5-사불분화청을산을지위원료,경과취대반응、수해탈최반응제비득도2,4,5-삼불분을산。해법조작간단、반응로선단、불사용극독청화물,위합성2,4,5-삼불분을산제공료신적도경。
2, 4, 5-Trifluorophenylacetic acid was synthesized from 1, 2, 4, 5-tetrafluorobenzene and ethyl cyanoacetate according to the substitution and the hydrolysis decarboxylation processes. This method was easily handled, the reaction route was short, and no toxic cyanide was used, which provide a new pathway to 2, 4, 5-trifluorophenylacetic acid.