CAJ | 학술논문

目的：检测并探讨鼻咽癌组织中E-钙粘蛋白（E-cadherin, E-cad）、表皮生长因子受体（Epidermal Growth Factor Receptor, EGFR）和基质金属蛋白酶9(matrix metalloproteinase-9, MMP-9)的表达与侵袭转移、预后的关系。方法选取62例鼻咽癌标本及45例癌旁组织标本，采用免疫组织化学染色方法（S-P法）检测鼻咽癌和癌旁组织中E-cad、EGFR、MMP-9的表达，并对所选病例进行随访。结果鼻咽癌组织中E-cad表达异常、EGFR及MMP-9的阳性表达率均高于癌旁组织，差异具有统计学意义（P＜0.05），且三者的表达率与临床分期、有无淋巴结转移有关（P＜0.05），与年龄、性别无关（P＞0.05）。结论检测鼻咽癌患者E-cad、EGFR、MMP-9的表达情况对判断其恶性程度及预后有重要意义。
목적：검측병탐토비인암조직중E-개점단백（E-cadherin, E-cad）、표피생장인자수체（Epidermal Growth Factor Receptor, EGFR）화기질금속단백매9(matrix metalloproteinase-9, MMP-9)적표체여침습전이、예후적관계。방법선취62례비인암표본급45례암방조직표본，채용면역조직화학염색방법（S-P법）검측비인암화암방조직중E-cad、EGFR、MMP-9적표체，병대소선병례진행수방。결과비인암조직중E-cad표체이상、EGFR급MMP-9적양성표체솔균고우암방조직，차이구유통계학의의（P＜0.05），차삼자적표체솔여림상분기、유무림파결전이유관（P＜0.05），여년령、성별무관（P＞0.05）。결론검측비인암환자E-cad、EGFR、MMP-9적표체정황대판단기악성정도급예후유중요의의。
Objective To study clinical relationship between the expression of E-cadherin(E-cad)、epidermal growth factor receptor (EGFR)、matrix metalloproteinase-9(MMP9)and Prognosis of nasopharyngeal carcinoma. Methods Immuno-histochemical method(S-P) was used to detect the expression of the E-cad、EGFR、MMP-9 in 62 cases of nasopharyngeal carcinoma and 45 cases of Nasopharyngeal normal tissues next to nasopharyngeal carcinoma. Results The positive expression rates of EGFR、MMP-9 and the abnormal expression rates of E-cad in the nasopharyngeal carcinoma were higher than those in the para-carcinoma tissues(P < 0.05). Significant differences were found between the expression of the E-cad、EGFR and MMP-9 in nasopharyngeal carcinoma and clinical stage、lymph node metastasis(P < 0.05).There was no significant correlation between E-cad、EGFR or MMP-9 expression and gender or age( P>0.05). Conclusion There was significantly important to detect the expression of the E-cad、EGFR and MMP-9, which could forecast the degree of malignancy and prognosis of nasopharyngeal carcinoma .