中国处方药
中國處方藥
중국처방약
CHINA PRESCRIPTION DRUG
2014年
1期
20-21
,共2页
邵建芳%王志成%王惠媛%丛林
邵建芳%王誌成%王惠媛%叢林
소건방%왕지성%왕혜원%총림
尼美舒利%非甾体抗炎药%不良反应
尼美舒利%非甾體抗炎藥%不良反應
니미서리%비치체항염약%불량반응
Nimesulide%Non-steroidal anti-inflammatory drugs%Hepatotoxicity
尼美舒利是非甾体类抗炎药,为选择性环氧化酶-2(COX-2)抑制剂,其耐受性好。近年来,尼美舒利因发生多起导致肝脏损害甚至死亡的严重药品不良反应病例,在一些国家已被停止销售。本文通过对国家药品不良反应监测系统相关数据的检索和分析及典型案例的评价,探讨尼美舒利肝脏损害不良反应,为临床安全、有效、合理用药提供参考。
尼美舒利是非甾體類抗炎藥,為選擇性環氧化酶-2(COX-2)抑製劑,其耐受性好。近年來,尼美舒利因髮生多起導緻肝髒損害甚至死亡的嚴重藥品不良反應病例,在一些國傢已被停止銷售。本文通過對國傢藥品不良反應鑑測繫統相關數據的檢索和分析及典型案例的評價,探討尼美舒利肝髒損害不良反應,為臨床安全、有效、閤理用藥提供參攷。
니미서리시비치체류항염약,위선택성배양화매-2(COX-2)억제제,기내수성호。근년래,니미서리인발생다기도치간장손해심지사망적엄중약품불량반응병례,재일사국가이피정지소수。본문통과대국가약품불량반응감측계통상관수거적검색화분석급전형안례적평개,탐토니미서리간장손해불량반응,위림상안전、유효、합리용약제공삼고。
Nimesulide, non-steroidal anti-inflammatory drug, is a selective cyclooxygenase-2(COX-2)inhibitor, which is well known for its tolerance and less adverse reactions. In recent years, due to Nimesulide hepatotoxicity that led to liver damage or even death, nimesulide has been stopped selling in some countries. Based on data retrieval and analysis from National Adverse Drug Reaction Monitoring system and typical case evaluation, we discussed the adverse reactions of Nimesulide hepatotoxicity, which may provide meaningful information for clinical safety from the aspect of effective and rational drug selection.