CAJ | 학술논문

目的：比较莫西沙星两种不同给药方案治疗老年社区获得性肺炎的临床作用。方法选择我院2010年10月～2011年12月收治的108例老年社区获得性肺炎患者并随机分为两组，对照组54例常规应用莫西沙星静脉滴注治疗，观察组54例采用莫西沙星序贯治疗，比较两组的临床疗效及药物经济学情况。结果观察组总有效率98.1%，对照组为94.4%，组间差异无统计学意义（P＞0.05）；观察组不良反应发生率为3.7%，对照组为7.4%，组间差异无统计学意义（P＞0.05）；观察组的成本-效果比为1834.9，明显低于对照组的3787.1，差异有统计学意义（P＜0.05）。结论莫西沙星两种不同给药方案治疗老年社区获得性肺炎均可获得满意的临床疗效，且安全性好，但序贯疗法成本-效果比低，是优选的治疗方案。
목적：비교막서사성량충불동급약방안치료노년사구획득성폐염적림상작용。방법선택아원2010년10월～2011년12월수치적108례노년사구획득성폐염환자병수궤분위량조，대조조54례상규응용막서사성정맥적주치료，관찰조54례채용막서사성서관치료，비교량조적림상료효급약물경제학정황。결과관찰조총유효솔98.1%，대조조위94.4%，조간차이무통계학의의（P＞0.05）；관찰조불량반응발생솔위3.7%，대조조위7.4%，조간차이무통계학의의（P＞0.05）；관찰조적성본-효과비위1834.9，명현저우대조조적3787.1，차이유통계학의의（P＜0.05）。결론막서사성량충불동급약방안치료노년사구획득성폐염균가획득만의적림상료효，차안전성호，단서관요법성본-효과비저，시우선적치료방안。
Objective To compare the clinical conditions of two different dosage regimens of Moxifloxacin in the treatment of community acquired pneumonia in elderly patients. Methods From October 2010 to December 2011 in our hospital, 108 elderly patients with community acquired pneumonia were selected and randomly divided into two groups, the control group(54 cases)treated with Moxifloxacin by conventional treatment, the observation group(40 cases)treated with Moxifloxacin by sequential treatment, the clinical efficacy and pharmacoeconomic efficacy of two groups were compared. Results The total ef ective rate of observation group was 98.1%,and the control group was 94.4%, there was no significant dif erence between two groups(P>0.05);the incidence of adverse reactions was 3.7%,and the control group was 7.4%, there was no significant dif erence between two groups (P>0.05);the cost-ef ectiveness ratio observation group was 1834.9, significantly lower than 3787.1 of the control group. Conclusion Two different dosage regimens of Moxifloxacin in the treatment of community acquired pneumonia in elderly patients can obtained satisfactory effect and good safety, but sequential treatment has lower cost-effectiveness ratio, it is the first choice of treatment program.