心电与循环
心電與循環
심전여순배
Journal of Electrocardiology(China)
2014年
1期
39-43
,共5页
李宁%项美香%李彬寅%林艳%金春娜%宋刘广
李寧%項美香%李彬寅%林豔%金春娜%宋劉廣
리저%항미향%리빈인%림염%금춘나%송류엄
尿酸%同型半胱氨酸%视黄醇结合蛋白4%冠心病
尿痠%同型半胱氨痠%視黃醇結閤蛋白4%冠心病
뇨산%동형반광안산%시황순결합단백4%관심병
Uric acid%Homocysteine%Retinol- binding protein4%Coronary heart disease
目的探讨血清同型半胱氨酸（Hcy）、尿酸、视黄醇结合蛋白4（RBP4）与冠心病的相关性。方法入院拟诊为冠心病的患者共603例，经冠状动脉造影确诊为冠心病的患者503例，根据临床特点分为心肌梗死组（MI组，n=84,包括急性和亚急性心肌梗死），不稳定型心绞痛组（UA组，n=312）和稳定型心绞痛组（SA组，n=107）。非冠心病100例作为对照组。检测并比较各组血清Hcy、尿酸、RBP4水平，采用Pearson作相关性分析，采用logistic多因素回归分析冠心病危险因素。结果血清Hcy、尿酸水平在不同分型的冠心病组均高于对照组（P＜0.05），且呈MI组＞UA组＞SA组＞对照组，各组间Hcy、尿酸比较差异有统计学意义（P＜0.05）；而RBP4在各组间差异无统计学意义（P＞0.05）。Hcy是冠心病的危险因素。Hcy、尿酸、RBP4均与吸烟史、TG、ApoA1相关，尿酸与Hcy、RBP4相关（P＜0.05或0.01）。结论 Hcy、尿酸与冠心病的发病密切相关，其血清水平高低与病变的严重程度相一致，Hcy是冠心病的危险因素。
目的探討血清同型半胱氨痠（Hcy）、尿痠、視黃醇結閤蛋白4（RBP4）與冠心病的相關性。方法入院擬診為冠心病的患者共603例，經冠狀動脈造影確診為冠心病的患者503例，根據臨床特點分為心肌梗死組（MI組，n=84,包括急性和亞急性心肌梗死），不穩定型心絞痛組（UA組，n=312）和穩定型心絞痛組（SA組，n=107）。非冠心病100例作為對照組。檢測併比較各組血清Hcy、尿痠、RBP4水平，採用Pearson作相關性分析，採用logistic多因素迴歸分析冠心病危險因素。結果血清Hcy、尿痠水平在不同分型的冠心病組均高于對照組（P＜0.05），且呈MI組＞UA組＞SA組＞對照組，各組間Hcy、尿痠比較差異有統計學意義（P＜0.05）；而RBP4在各組間差異無統計學意義（P＞0.05）。Hcy是冠心病的危險因素。Hcy、尿痠、RBP4均與吸煙史、TG、ApoA1相關，尿痠與Hcy、RBP4相關（P＜0.05或0.01）。結論 Hcy、尿痠與冠心病的髮病密切相關，其血清水平高低與病變的嚴重程度相一緻，Hcy是冠心病的危險因素。
목적탐토혈청동형반광안산（Hcy）、뇨산、시황순결합단백4（RBP4）여관심병적상관성。방법입원의진위관심병적환자공603례，경관상동맥조영학진위관심병적환자503례，근거림상특점분위심기경사조（MI조，n=84,포괄급성화아급성심기경사），불은정형심교통조（UA조，n=312）화은정형심교통조（SA조，n=107）。비관심병100례작위대조조。검측병비교각조혈청Hcy、뇨산、RBP4수평，채용Pearson작상관성분석，채용logistic다인소회귀분석관심병위험인소。결과혈청Hcy、뇨산수평재불동분형적관심병조균고우대조조（P＜0.05），차정MI조＞UA조＞SA조＞대조조，각조간Hcy、뇨산비교차이유통계학의의（P＜0.05）；이RBP4재각조간차이무통계학의의（P＞0.05）。Hcy시관심병적위험인소。Hcy、뇨산、RBP4균여흡연사、TG、ApoA1상관，뇨산여Hcy、RBP4상관（P＜0.05혹0.01）。결론 Hcy、뇨산여관심병적발병밀절상관，기혈청수평고저여병변적엄중정도상일치，Hcy시관심병적위험인소。
Objective To analyze the correlation of serum homocysteine(Hcy), uric acid and retinol- binding protein4 (RBP4) with coronary heart disease (CHD). Methods 503 cases with CHD diagnosed by coronary angiography were classified into MI group (n=84, including acute and subacute myocardial infarction), unstable angina (UA) group (n=312) and stable angina (SA) group (n=107) based on their clinical characteristics. 100 cases without CHD were included as control group. Serum Hcy, uric acid and RBP4 were measured and their correlations were determined by Pearson test. The risk factors for CHD were analyzed by multivariate logistic regression. Results The level of Hcy and uric acid, but not RBP4, were significantly higher in MI,UA and SA groups than those in control group (P<0.05), ranked in the order of MI group>UA group>SA group>control group. Multivariate logistic regression analysis showed that Hcy was a risk factor for CHD. Hcy, uric acid and RBP4 were correlated to smoking, TG and ApoA1. Uric acid was correlated to Hcy and RBP4. Conclusion Hcy and uric acid are obviously associated with CHD. Their serum levels are consistent with the severity of CHD. Hcy is a risk factor for CHD.
