实用肝脏病杂志
實用肝髒病雜誌
실용간장병잡지
JOURNAL OF CLINICAL HEPATOLOGY
2014年
1期
65-67
,共3页
肝细胞癌%慢性乙型肝炎%分泌型卷曲相关蛋白-1%β-catenin
肝細胞癌%慢性乙型肝炎%分泌型捲麯相關蛋白-1%β-catenin
간세포암%만성을형간염%분비형권곡상관단백-1%β-catenin
Hepatocellular carcinoma%Hepatitis B%Secreted frizzled-related proteins -1%β-catenin
目的：探讨肝细胞癌（hepatocellular carcinoma， HCC）和慢性乙型肝炎（chronic hepatitis B，CHB）患者血清分泌型卷曲相关蛋白-1（secreted frizzled-related proteins， sFRP-1）和β-catenin水平及临床意义。方法采用ELISA法检测36例HCC、36例CHB和36例正常人血清sFRP-1和β-catenin水平，应用Spearman相关分析，分析血清sFRP-1和β-catenin水平与年龄、丙氨酸氨基转移酶（ALT）、白蛋白和总胆红素等的相关性。结果 HCC和CHB患者血清sFRP-1水平分别为（1136.28±332.43）pg/ml和（1194.53±156.84）pg/ml，均显著低于正常人[（1477.26±563.12）pg/ml，P＜0.05]；HCC患者血清β-catenin水平为（527.2±20.9）pg/ml，显著高于正常人和CHB患者[分别为（369.8±21.5）pg/ml和（374.0±8.3）pg/ml，P＜0.05]；HCC和CHB患者血清sFRP-1和β-catenin水平与年龄、ALT、白蛋白、总胆红素无显著相关性。结论肝细胞癌和慢性乙型肝炎患者血清sFRP-1降低，而肝细胞癌患者血清β-catenin水平升高。
目的：探討肝細胞癌（hepatocellular carcinoma， HCC）和慢性乙型肝炎（chronic hepatitis B，CHB）患者血清分泌型捲麯相關蛋白-1（secreted frizzled-related proteins， sFRP-1）和β-catenin水平及臨床意義。方法採用ELISA法檢測36例HCC、36例CHB和36例正常人血清sFRP-1和β-catenin水平，應用Spearman相關分析，分析血清sFRP-1和β-catenin水平與年齡、丙氨痠氨基轉移酶（ALT）、白蛋白和總膽紅素等的相關性。結果 HCC和CHB患者血清sFRP-1水平分彆為（1136.28±332.43）pg/ml和（1194.53±156.84）pg/ml，均顯著低于正常人[（1477.26±563.12）pg/ml，P＜0.05]；HCC患者血清β-catenin水平為（527.2±20.9）pg/ml，顯著高于正常人和CHB患者[分彆為（369.8±21.5）pg/ml和（374.0±8.3）pg/ml，P＜0.05]；HCC和CHB患者血清sFRP-1和β-catenin水平與年齡、ALT、白蛋白、總膽紅素無顯著相關性。結論肝細胞癌和慢性乙型肝炎患者血清sFRP-1降低，而肝細胞癌患者血清β-catenin水平升高。
목적：탐토간세포암（hepatocellular carcinoma， HCC）화만성을형간염（chronic hepatitis B，CHB）환자혈청분비형권곡상관단백-1（secreted frizzled-related proteins， sFRP-1）화β-catenin수평급림상의의。방법채용ELISA법검측36례HCC、36례CHB화36례정상인혈청sFRP-1화β-catenin수평，응용Spearman상관분석，분석혈청sFRP-1화β-catenin수평여년령、병안산안기전이매（ALT）、백단백화총담홍소등적상관성。결과 HCC화CHB환자혈청sFRP-1수평분별위（1136.28±332.43）pg/ml화（1194.53±156.84）pg/ml，균현저저우정상인[（1477.26±563.12）pg/ml，P＜0.05]；HCC환자혈청β-catenin수평위（527.2±20.9）pg/ml，현저고우정상인화CHB환자[분별위（369.8±21.5）pg/ml화（374.0±8.3）pg/ml，P＜0.05]；HCC화CHB환자혈청sFRP-1화β-catenin수평여년령、ALT、백단백、총담홍소무현저상관성。결론간세포암화만성을형간염환자혈청sFRP-1강저，이간세포암환자혈청β-catenin수평승고。
Objective To evaluate serum levels and clinical significance of secreted frizzled-related proteins (sFRP)-1 and β-catenin in patients with hepatocellular carcinoma(HCC)and chronic hepatitis B (CHB). Meth-ods Serum levels of sFRP-1 and β-catenin in 36 patients with HCC,36 patients with CHB and 36 healthy per-sons were detected by ELISA;Spearman correlation analysis was used to estimate the relevance between sFRP-1,β-catenin and age,ALT,albumin,total bilirubin. Results The serum levels of sFRP-1 in patients with HCC and CHB were(1136.28 ±332.43) pg/ml and(1194.53 ±156.84) pg/ml,respectively,both significantly higher than that in healthy persons [(1477.26±563.12) pg/ml,P<0.05];The serum level of β-catenin in patients with HCC was (527.2± 20.9) pg/ml,significantly higher than those in patients with CHB(374.0±8.3) pg/ml and normal persons (369.8± 21.5) pg/ml,P<0.05);No correlation was found between serum sFRP-1 or β-catenin levels with age,ALT,albu-min,total bilirubin either in CHB or in HCC group. Conclusion The serum sFRP-1 levels in patients with HCC and CHB decrease,while the serum β-catenin levels in patients with HCC increase.
