国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
17期
2686-2688
,共3页
彭怀力%陈玲%曹枫%陈荣琳%欧寿六
彭懷力%陳玲%曹楓%陳榮琳%歐壽六
팽부력%진령%조풍%진영림%구수륙
持续性血液净化%重症急性胰腺炎%RAAS%炎性因子
持續性血液淨化%重癥急性胰腺炎%RAAS%炎性因子
지속성혈액정화%중증급성이선염%RAAS%염성인자
Continuous blood purification%Severe acute pancreatitis%RAAS%Inflammatory factor
目的 探讨持续性血液净化技术在重症急性胰腺炎治疗中的效果.方法 23例患者接受传统临床药物治疗,23患者在此基础上加上持续性血液净化技术,对比两组患者炎性因子等指标改善的情况.结果 治疗24 h后,观察组IL-1、IL-6、IL-8、TNF-α分别为(246.52±31.84)pg/ml、(15.12±1.07) pg/ml、(16.05±1.08) pg/ml、(1.42±0.31)ng/L,治疗48 h后,观察组IL-1、IL-6、IL-8、TNF-α分别为(190.46±27.65) pg/ml、(11.07±1.87) pg/ml、(11.04±1.57)pg/m1、(0.68±0.34) ng/L,均显著低于治疗前,差异有统计学意义(P＜0.05),且观察组指标明显低于对照组.治疗24 h后,观察组Ang-Ⅰ、Ang-Ⅱ、E、ALD分别为(1.34±1.17)ng/L、(0.72±5.37)ng/L、(1.05±0.21) ng/ml、(145.27±15.34) pg/ml,治疗48 h后,观察组Ang-Ⅰ、Ang-Ⅱ、E、ALD分别为(9.28±1.16) ng/L、(48.42±4.10) ng/L、(0.63±0.11) ng/ml、(99.31±11.16)pg/ml,均显著低于治疗前,差异有统计学意义(P＜0.05),且观察组指标明显低于对照组.结论 CBP可以明显缓解SAP病情,促进炎性因子和RAAS系统的改善.
目的 探討持續性血液淨化技術在重癥急性胰腺炎治療中的效果.方法 23例患者接受傳統臨床藥物治療,23患者在此基礎上加上持續性血液淨化技術,對比兩組患者炎性因子等指標改善的情況.結果 治療24 h後,觀察組IL-1、IL-6、IL-8、TNF-α分彆為(246.52±31.84)pg/ml、(15.12±1.07) pg/ml、(16.05±1.08) pg/ml、(1.42±0.31)ng/L,治療48 h後,觀察組IL-1、IL-6、IL-8、TNF-α分彆為(190.46±27.65) pg/ml、(11.07±1.87) pg/ml、(11.04±1.57)pg/m1、(0.68±0.34) ng/L,均顯著低于治療前,差異有統計學意義(P＜0.05),且觀察組指標明顯低于對照組.治療24 h後,觀察組Ang-Ⅰ、Ang-Ⅱ、E、ALD分彆為(1.34±1.17)ng/L、(0.72±5.37)ng/L、(1.05±0.21) ng/ml、(145.27±15.34) pg/ml,治療48 h後,觀察組Ang-Ⅰ、Ang-Ⅱ、E、ALD分彆為(9.28±1.16) ng/L、(48.42±4.10) ng/L、(0.63±0.11) ng/ml、(99.31±11.16)pg/ml,均顯著低于治療前,差異有統計學意義(P＜0.05),且觀察組指標明顯低于對照組.結論 CBP可以明顯緩解SAP病情,促進炎性因子和RAAS繫統的改善.
목적 탐토지속성혈액정화기술재중증급성이선염치료중적효과.방법 23례환자접수전통림상약물치료,23환자재차기출상가상지속성혈액정화기술,대비량조환자염성인자등지표개선적정황.결과 치료24 h후,관찰조IL-1、IL-6、IL-8、TNF-α분별위(246.52±31.84)pg/ml、(15.12±1.07) pg/ml、(16.05±1.08) pg/ml、(1.42±0.31)ng/L,치료48 h후,관찰조IL-1、IL-6、IL-8、TNF-α분별위(190.46±27.65) pg/ml、(11.07±1.87) pg/ml、(11.04±1.57)pg/m1、(0.68±0.34) ng/L,균현저저우치료전,차이유통계학의의(P＜0.05),차관찰조지표명현저우대조조.치료24 h후,관찰조Ang-Ⅰ、Ang-Ⅱ、E、ALD분별위(1.34±1.17)ng/L、(0.72±5.37)ng/L、(1.05±0.21) ng/ml、(145.27±15.34) pg/ml,치료48 h후,관찰조Ang-Ⅰ、Ang-Ⅱ、E、ALD분별위(9.28±1.16) ng/L、(48.42±4.10) ng/L、(0.63±0.11) ng/ml、(99.31±11.16)pg/ml,균현저저우치료전,차이유통계학의의(P＜0.05),차관찰조지표명현저우대조조.결론 CBP가이명현완해SAP병정,촉진염성인자화RAAS계통적개선.
Objective To investigate the effect of continuous blood purification therapy in treatment of severe acute pancreatitis (SAP).Methods 23 patients were treated with traditional clinical medicine,23patients were treated on the basis of the former,with continuous blood purification (CBP) technology added,the inflammatory factors and other indicators of the situation in both groups were compared,Results There was significant difference of IL-1,IL-6,IL-8 and TNF-α treatment of two groups of patients in the time of 24h and 48h after treatment (P ＜ 0.05),observed indexes were significantly lower than those of the control group [IL-1,IL-6,IL-8,TNF-α were (246.52 ± 31.84) pg/ml,(15.12 ± 1.07) pg/ml,(16.05 ± 1.08) pg/ml and (1.42 ± 0.31) ng/L 24 h after treatment (190.46 ± 27.65) pg/ml,(11.07 ± 1.87) pg/ml,(11.04 ± 1.57) pg/ml and (0.68 ± 0.34) ng/L 48 h after treatment respectively].There was significant difference of Ang-Ⅰ,Ang-Ⅱ,E,aldosterone in the treatment of the two groups patients in the time of 24 h and 48 h after treatment (P ＜ 0.05) [Ang-Ⅰ,Ang-Ⅱ,E,ALD were (1.34 ± 1.17) ng/L,(0.72 ± 5.37) ng/L,(1.05 ± 0.21) ng/ml and (145.27 ± 15.34)pg/ml 24 h later,(9.28 ± 1.16) ng/L,(48.42 ± 4.10) ng/L,(0.63 ± 0.11) ng/ml and (99.31 ± 11,16) pg/ml 48 h later].Conclusion CBP can obviously alleviate the severity of SAP,and promote the inflammatory factors and improve the renin-angiotensin-aldosterone system.
