实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
5期
561-563
,共3页
食管癌%调强放疗%大体肿瘤体积%肿瘤退缩率
食管癌%調彊放療%大體腫瘤體積%腫瘤退縮率
식관암%조강방료%대체종류체적%종류퇴축솔
Esophageal carcinoma%Intensity-modulated radiation therapy ( IMRT)%Gross tumor volume ( GTV)%Volume reduction rate ( VRR)
目的：探讨食管癌调强放疗肿瘤退缩的规律及其应用价值。方法回顾性分析38例行调强放疗的食管癌患者在治疗过程中的肿瘤影像学资料，比较外照射前、照射至中位剂量达32 Gy时、放疗结束时和放疗后6个月内患者实体肿瘤体积（ gross tumor volume ，GTV）变化情况，以及放疗前半程、放疗后半程和放疗全程体积退缩率（ volume re-duction rate，VRR）。结果患者外照射前GTV范围为（5．49～110．39）ml，平均值为（32．78±5．33）ml，照射至中位剂量32 Gy时GTV范围为（4．89～80．15）ml，平均值为（23．56±3．40）ml，放疗结束时GTV范围为（4．47～78．88）ml，平均值为（21．57±3．06）ml，放疗后6个月GTV范围为（5．06～32．96）ml，平均值为（15．89±2．28）ml。患者放疗前半程VRR范围为-0．040～0．622，平均值为（0．193±0．032），放疗后半程VRR 范围为-0．414～0．311，平均值为（0．050±0．030），放疗全程VRR范围为-0．267～0．695，平均值为（0．225±0．046）；放疗前半程患者VRR明显高于后半程，差异具有统计学意义（P＜0．05）。结论食管癌患者放疗过程中肿瘤体积不断缩退，缩退过程主要集中于放疗前半程，放疗师需及时根据影像学检查结果调整靶区及放射剂量，保证在靶区高剂量照射的同时降低周围组织受量。
目的：探討食管癌調彊放療腫瘤退縮的規律及其應用價值。方法迴顧性分析38例行調彊放療的食管癌患者在治療過程中的腫瘤影像學資料，比較外照射前、照射至中位劑量達32 Gy時、放療結束時和放療後6箇月內患者實體腫瘤體積（ gross tumor volume ，GTV）變化情況，以及放療前半程、放療後半程和放療全程體積退縮率（ volume re-duction rate，VRR）。結果患者外照射前GTV範圍為（5．49～110．39）ml，平均值為（32．78±5．33）ml，照射至中位劑量32 Gy時GTV範圍為（4．89～80．15）ml，平均值為（23．56±3．40）ml，放療結束時GTV範圍為（4．47～78．88）ml，平均值為（21．57±3．06）ml，放療後6箇月GTV範圍為（5．06～32．96）ml，平均值為（15．89±2．28）ml。患者放療前半程VRR範圍為-0．040～0．622，平均值為（0．193±0．032），放療後半程VRR 範圍為-0．414～0．311，平均值為（0．050±0．030），放療全程VRR範圍為-0．267～0．695，平均值為（0．225±0．046）；放療前半程患者VRR明顯高于後半程，差異具有統計學意義（P＜0．05）。結論食管癌患者放療過程中腫瘤體積不斷縮退，縮退過程主要集中于放療前半程，放療師需及時根據影像學檢查結果調整靶區及放射劑量，保證在靶區高劑量照射的同時降低週圍組織受量。
목적：탐토식관암조강방료종류퇴축적규률급기응용개치。방법회고성분석38례행조강방료적식관암환자재치료과정중적종류영상학자료，비교외조사전、조사지중위제량체32 Gy시、방료결속시화방료후6개월내환자실체종류체적（ gross tumor volume ，GTV）변화정황，이급방료전반정、방료후반정화방료전정체적퇴축솔（ volume re-duction rate，VRR）。결과환자외조사전GTV범위위（5．49～110．39）ml，평균치위（32．78±5．33）ml，조사지중위제량32 Gy시GTV범위위（4．89～80．15）ml，평균치위（23．56±3．40）ml，방료결속시GTV범위위（4．47～78．88）ml，평균치위（21．57±3．06）ml，방료후6개월GTV범위위（5．06～32．96）ml，평균치위（15．89±2．28）ml。환자방료전반정VRR범위위-0．040～0．622，평균치위（0．193±0．032），방료후반정VRR 범위위-0．414～0．311，평균치위（0．050±0．030），방료전정VRR범위위-0．267～0．695，평균치위（0．225±0．046）；방료전반정환자VRR명현고우후반정，차이구유통계학의의（P＜0．05）。결론식관암환자방료과정중종류체적불단축퇴，축퇴과정주요집중우방료전반정，방료사수급시근거영상학검사결과조정파구급방사제량，보증재파구고제량조사적동시강저주위조직수량。
Objective To explore the clinical value of tumor regression during IMRT treatment for esophageal cancer . Methods Image data of 38 esophageal cancer patients treated with IMRT were retrospectively analyzed .Gross tumor volume ( GTV) were compared at the begin of radiation ,radiation dose of 32 Gy,the end of radiation and 6 months later,volume reduction rate ( VRR) were compared at the first half of radiation therapy ,second half of radiotherapy and the whole radiation .Results The range of GTV at the begin of radiation was 5.49~110.39ml,the average was (32.78 ±5.33) ml,the range of GTV at the ra-diation dose of 32 Gy was 4.89~80.15ml,the average was (23.56 ±3.40)ml,the range of GTV at the end of radiation was 4.47~78.88ml,the average was (21.57 ±3.06) ml,the range of GTV after 6 months was (5.06 ~32.96) ml,the average was (15.89 ±2.28)ml;The range of VRR at the first half of radiation therapy was -0.040 ~0.622,the average was (0.193 ± 0.032),the range of VRR at the second half of radiotherapy -0.414~0.311,the average was (0.050 ±0.030),the range of VRR at the whole radiation was -0.267~0.695,the average was (0.225 ±0.046);The VRR at the first half of radiation thera-py was higher than that of the second half of radiotherapy (P<0.05).Conclusion The first half tumor regression rate is greater than the second half in IMRT treatment for esophageal cancer ,the medical radiation therapist should adjust the target and radia-tion dose according to the results of iconography ,to ensure high dose irradiation in the target area and reduce the amount of the surrounding tissue .
