CAJ | 학술논문

Nuss 与 Ravitch 两种术式对漏斗胸患儿免疫功能影响的对比研究
Nuss 여 Ravitch 량충술식대루두흉환인면역공능영향적대비연구
The comparative study of Nuss surgery and Ravitch procedure to pectus excavatum children’ s immune functional effect

万方数据

河北医药河北醫藥 하북의약
HEBEI MEDICAL JOURNAL
2014年 1期 20-22 ,共3页

王贤书%张晓茹%杨志国%李鑫%程征海%岳芳%方江顺%陈志国%景世元%曹红宾%赵令

왕현서%장효여%양지국%리흠%정정해%악방%방강순%진지국%경세원%조홍빈%조령

漏斗胸%Nuss手术%Ravitch手术%免疫球蛋白漏鬥胸%Nuss手術%Ravitch手術%免疫毬蛋白
루두흉%Nuss수술%Ravitch수술%면역구단백
pectus excavatum%nuss surgery%ravitch procedure%immunoglobulin

目的：通过检测经Nuss手术及Ravitch手术治疗的先天性漏斗胸患儿手术前后的免疫指标，对比研究两种手术方式对漏斗胸患儿术后早期免疫功能的影响。方法回顾性分析80例漏斗胸手术，其中行Nuss手术40例（ Nuss组），Ravitch手术40例（ Ravitch组），2组分别于术前及术后第7天检测血清免疫球蛋白IgG、IgA、IgM含量。结果术前比较2组患儿的血清IgG、IgA、IgM含量无明显差异（ P ＞0．05），术后第7天检测显示Nuss组患儿血清IgG、IgA、IgM含量较Ravitch组患儿明显升高，差异有统计学意义（ P ＜0．05）；Nuss组中，术后7 d血清IgG、IgA、IgM与术前相比均有明显升高（ P ＜0．05），而Ravitch组中仅IgA含量在术后7 d与术前比较有明显差异（ P ＜0．05），IgG和IgM术后7 d与术前比较，差异均无统计学意义（ P ＞0．05）。结论 Nuss手术较Ravitch手术创伤性小，患儿术后机体免疫力恢复较早，更有利于患儿康复；免疫指标的检测可以作为评估漏斗胸患儿术后手术疗效及预后的辅助手段之一。
목적：통과검측경Nuss수술급Ravitch수술치료적선천성루두흉환인수술전후적면역지표，대비연구량충수술방식대루두흉환인술후조기면역공능적영향。방법회고성분석80례루두흉수술，기중행Nuss수술40례（ Nuss조），Ravitch수술40례（ Ravitch조），2조분별우술전급술후제7천검측혈청면역구단백IgG、IgA、IgM함량。결과술전비교2조환인적혈청IgG、IgA、IgM함량무명현차이（ P ＞0．05），술후제7천검측현시Nuss조환인혈청IgG、IgA、IgM함량교Ravitch조환인명현승고，차이유통계학의의（ P ＜0．05）；Nuss조중，술후7 d혈청IgG、IgA、IgM여술전상비균유명현승고（ P ＜0．05），이Ravitch조중부IgA함량재술후7 d여술전비교유명현차이（ P ＜0．05），IgG화IgM술후7 d여술전비교，차이균무통계학의의（ P ＞0．05）。결론 Nuss수술교Ravitch수술창상성소，환인술후궤체면역력회복교조，경유리우환인강복；면역지표적검측가이작위평고루두흉환인술후수술료효급예후적보조수단지일。
Objective To comparatively study the effects of two surgical methods on early postoperative immune function of pectus excavatum in children by detecting the immune parameters of children before and after surgery who had congenital funnel chest and treated by Nuss surgery and Ravitch procedure .Methods A retrospective analysis of ten years 80 cases of funnel chest surgery ,among which Nuss surgery 40 cases,and Ravitch operation 40 cases,the serum immunoglobulins IgG,IgA,IgM levels of two groups were detected at the preoperative and 7d after surgery.Results Preoperative serum IgG, IgA,IgM of the two groups children showed no significant difference ( P >0.05),while the tests at 7d after surgery showed that serum IgG,IgA,IgM levels of Nuss group children significantly were higher than Ravitch group children ,the difference was statistically significant ( P <0.05 ); Serum IgG, IgA, IgM contents of Nuss group children at 7d after surgery were significantly higher than the preoperative ( P <0.05),while the Ravitch group,compared with the preoperative,only IgA content at 7d after surgery has significant difference ( P <0.05),IgG and IgM contents have no statistical difference ( P >0.05).Co nclusion Compared with Ravitch procedure,Nuss surgery has smaller trauma on the body,earlier recovery of immunity after surgery ,and better rehabilitation of children; The detection of immune parameters can be used as one of the auxiliary means to assess the efficacy after surgery and prognosis of patients .