河北医药
河北醫藥
하북의약
HEBEI MEDICAL JOURNAL
2014年
1期
5-7
,共3页
闫文升%薛岩%孙幸%杨欢%康洁%康云霄%张国梁
閆文升%薛巖%孫倖%楊歡%康潔%康雲霄%張國樑
염문승%설암%손행%양환%강길%강운소%장국량
丙酸睾丸酮%鼻腔给药%旷场试验%行为%大鼠,雌性
丙痠睪汍酮%鼻腔給藥%曠場試驗%行為%大鼠,雌性
병산고환동%비강급약%광장시험%행위%대서,자성
testosterone%intranasal administration%open field test%behavior%female rats
目的：观察雌性大鼠长期鼻腔给予丙酸睾丸酮后的旷场行为变化，推测鼻腔给予丙酸睾丸酮对中枢神经系统的影响。方法通过旷场实验观察雌性大鼠鼻腔给予丙酸睾丸酮后静止闻嗅行为、探索行为、趋触性行为、运动行为和理毛行为的变化。结果 Intact-T组的静止状态闻嗅次数比正常组增加了47％（ P ＜0．05）。 Intact-T组大鼠鼻腔给予丙酸睾丸酮后climbing、 rearing 和sniffing 行为次数比正常组分别减少了43％（ P ＜0．05）、56％（ P ＜0．05）和40％（ P ＜0．05）。 Intact-T组大鼠鼻腔给予丙酸睾丸酮后垂直运动、水平运动和总径长比正常组分别减少了46％、45％和42％（ P均＜0．05）。 Intact-T组大鼠鼻腔给予丙酸睾丸酮后理毛潜伏期比正常组减少了84％（ P＜0．05），理毛数量和理毛持续时间比正常组分别增加了48％和41％。结论长期鼻腔给予丙酸睾丸酮增加了雌性大鼠的静止行为，减少了其活动行为。
目的：觀察雌性大鼠長期鼻腔給予丙痠睪汍酮後的曠場行為變化，推測鼻腔給予丙痠睪汍酮對中樞神經繫統的影響。方法通過曠場實驗觀察雌性大鼠鼻腔給予丙痠睪汍酮後靜止聞嗅行為、探索行為、趨觸性行為、運動行為和理毛行為的變化。結果 Intact-T組的靜止狀態聞嗅次數比正常組增加瞭47％（ P ＜0．05）。 Intact-T組大鼠鼻腔給予丙痠睪汍酮後climbing、 rearing 和sniffing 行為次數比正常組分彆減少瞭43％（ P ＜0．05）、56％（ P ＜0．05）和40％（ P ＜0．05）。 Intact-T組大鼠鼻腔給予丙痠睪汍酮後垂直運動、水平運動和總徑長比正常組分彆減少瞭46％、45％和42％（ P均＜0．05）。 Intact-T組大鼠鼻腔給予丙痠睪汍酮後理毛潛伏期比正常組減少瞭84％（ P＜0．05），理毛數量和理毛持續時間比正常組分彆增加瞭48％和41％。結論長期鼻腔給予丙痠睪汍酮增加瞭雌性大鼠的靜止行為，減少瞭其活動行為。
목적：관찰자성대서장기비강급여병산고환동후적광장행위변화，추측비강급여병산고환동대중추신경계통적영향。방법통과광장실험관찰자성대서비강급여병산고환동후정지문후행위、탐색행위、추촉성행위、운동행위화리모행위적변화。결과 Intact-T조적정지상태문후차수비정상조증가료47％（ P ＜0．05）。 Intact-T조대서비강급여병산고환동후climbing、 rearing 화sniffing 행위차수비정상조분별감소료43％（ P ＜0．05）、56％（ P ＜0．05）화40％（ P ＜0．05）。 Intact-T조대서비강급여병산고환동후수직운동、수평운동화총경장비정상조분별감소료46％、45％화42％（ P균＜0．05）。 Intact-T조대서비강급여병산고환동후리모잠복기비정상조감소료84％（ P＜0．05），리모수량화리모지속시간비정상조분별증가료48％화41％。결론장기비강급여병산고환동증가료자성대서적정지행위，감소료기활동행위。
Objectiev To investigate the effects of long-term intranasal administration of testosterone propionate on the central nervous system by analyzing the open field behavior of rats .Methods The open field test was used to analyze five types of behavioral patterns of female rats including static sniffing behavior ,exploratory behavior,thigmotaxis behavior,motor behavior and grooming behavior .Re sults After intranasal administration of testosterone propionate the static sniffing number of times in intact-T group were increased by 47%,as compared with those in intact group ( P <0.05).The number of times of climbing,rearing and sniffing behavior in intact T group were decreased by 43%,56%,40%,respectively,as compared with those in intact group ( P <0.05).The vertical activity,horizontal activity and the total path length in intact T group were decreased by 46%, 45%, 42%, respectively , as compared with those in intact group ( P <0 .05 ) .The latency time of grooming in intact T group was decreased by 84%,however,grooming events and the duration of grooming were increased by 48%,as compared with those in intact group ( P <0.05).Conclusion The long-term intranasal administration of testosterone propionate can increase static behaviors of female rats ,however,which can decrease the rats'activity behaviors in open field test .
