中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
14期
56-57,58
,共3页
单唾液酸四已糖神经节苷酯%胞二磷胆碱%新生儿%缺氧缺血性脑病
單唾液痠四已糖神經節苷酯%胞二燐膽堿%新生兒%缺氧缺血性腦病
단타액산사이당신경절감지%포이린담감%신생인%결양결혈성뇌병
Monosialotetrahexosylganglioside%Citicoline%Neonatal%Hypoxic-Ischemic Emcephalopathy
目的：探讨单唾液酸四已糖神经节苷酯联合胞二磷胆碱治疗中、重度新生儿缺氧缺血性脑病（HIE）的临床疗效。方法：将本院儿科2010年1月-2013年1月住院的中、重度HIE患儿98例按随机数字表法分为治疗组和对照组，均采用三维持、三对症的综合治疗方案。对照组49例加用胞二磷胆碱（CDPC）治疗，治疗组49例在对照组的基础上加用单唾液酸四已糖神经节苷酯（GM-1）进行治疗，观察两组患儿的症状体征，行脑CT判定和NBNA评分评估疗效。结果：治疗组临床疗效总有效率为93.88%，显著高于对照组（P<0.05）；脑CT变化比较：治疗组明显优于对照组（P<0.05）；NABA评分：治疗组与对照组在生后2 d内评分差异无统计学意义（P>0.05），生后7、14、28 d评分治疗组明显高于对照组，差异均具有统计学意义（P<0.05）。结论：GM-1与CDPC合用可发挥协同作用，促进受损神经细胞功能修复，逆转脑缺氧缺血后神经功能障碍，显著提高脑机能，可明显改善中重度HIE的临床症状，适于临床推广。
目的：探討單唾液痠四已糖神經節苷酯聯閤胞二燐膽堿治療中、重度新生兒缺氧缺血性腦病（HIE）的臨床療效。方法：將本院兒科2010年1月-2013年1月住院的中、重度HIE患兒98例按隨機數字錶法分為治療組和對照組，均採用三維持、三對癥的綜閤治療方案。對照組49例加用胞二燐膽堿（CDPC）治療，治療組49例在對照組的基礎上加用單唾液痠四已糖神經節苷酯（GM-1）進行治療，觀察兩組患兒的癥狀體徵，行腦CT判定和NBNA評分評估療效。結果：治療組臨床療效總有效率為93.88%，顯著高于對照組（P<0.05）；腦CT變化比較：治療組明顯優于對照組（P<0.05）；NABA評分：治療組與對照組在生後2 d內評分差異無統計學意義（P>0.05），生後7、14、28 d評分治療組明顯高于對照組，差異均具有統計學意義（P<0.05）。結論：GM-1與CDPC閤用可髮揮協同作用，促進受損神經細胞功能脩複，逆轉腦缺氧缺血後神經功能障礙，顯著提高腦機能，可明顯改善中重度HIE的臨床癥狀，適于臨床推廣。
목적：탐토단타액산사이당신경절감지연합포이린담감치료중、중도신생인결양결혈성뇌병（HIE）적림상료효。방법：장본원인과2010년1월-2013년1월주원적중、중도HIE환인98례안수궤수자표법분위치료조화대조조，균채용삼유지、삼대증적종합치료방안。대조조49례가용포이린담감（CDPC）치료，치료조49례재대조조적기출상가용단타액산사이당신경절감지（GM-1）진행치료，관찰량조환인적증상체정，행뇌CT판정화NBNA평분평고료효。결과：치료조림상료효총유효솔위93.88%，현저고우대조조（P<0.05）；뇌CT변화비교：치료조명현우우대조조（P<0.05）；NABA평분：치료조여대조조재생후2 d내평분차이무통계학의의（P>0.05），생후7、14、28 d평분치료조명현고우대조조，차이균구유통계학의의（P<0.05）。결론：GM-1여CDPC합용가발휘협동작용，촉진수손신경세포공능수복，역전뇌결양결혈후신경공능장애，현저제고뇌궤능，가명현개선중중도HIE적림상증상，괄우림상추엄。
Objective:To investigate the clinical effieacy of the Monosialotetrahexosylganglioside(GM-1) combined with citicoline in the treatment of severe neonatal hypoxic-ischemic encephalopathy(HIE). Method:From January 2010 to January 2010 ,the data of 98 children with severe HIE were retrospectively analyzed in department of pediatric in our hospital. All the cases were treated by three in the support and the basis of the three symptomatic .The control group(n=49) was treated with citicoline(CDPC)together with conventional trerapy for HIE. The treatment group(n=49)was treated with GM-1 on the basis of the control group. The symptoms and signs of the two groups were observed.Brain CT and the neonatal behavioral neurological assessment(NBNA)scores of the two groups were evaluated. Result:The total effective rate in the observation group was 93.86%,significantly higher than that in the control group. Brain CT changes in treatment group was better than that in the control group.The NBNA scores(2 d)in the treatment group was no significant difference,the NBNA scores(7,14,28 d)were significantly higher than those in the control group(P<0.05).Conclusion:GM-1 combined with Citicoline could significantly promote the injury central nerous system functional recovery and improve brain dysfunction in treatment of maderate and severe neonatal HIE. Thus it’s worthy of clinical application.
