CAJ | 학술논문

以具有良好生物相容性、生物可降解性的聚乳酸-聚己内酯(PLCL)和聚左旋乳酸(PLLA)为原料,通过静电纺丝法,以70∶30为质量比的 SF/COL 分别和聚左旋乳酸、聚左旋乳酸-己内酯共混制备不同质量比的纳米纤维支架材料。采用 X射线衍射、热重分析等方法对复合材料的理化性能进行表征并对其交联前后的性能进行探讨和比较。结果表明,SF/COL 与高分子聚合物复合后其分子结构和热稳定性变化不明显,交联后复合纳米纤维支架β化程度、结晶度和热稳定性较交联前均有所增加,能形成稳定的分子构象,热稳定性有所提高,在组织工程中可为特定细胞提供结构支持,有望成为一种新型的组织工程支架材料。
이구유량호생물상용성、생물가강해성적취유산-취기내지(PLCL)화취좌선유산(PLLA)위원료,통과정전방사법,이70∶30위질량비적 SF/COL 분별화취좌선유산、취좌선유산-기내지공혼제비불동질량비적납미섬유지가재료。채용 X사선연사、열중분석등방법대복합재료적이화성능진행표정병대기교련전후적성능진행탐토화비교。결과표명,SF/COL 여고분자취합물복합후기분자결구화열은정성변화불명현,교련후복합납미섬유지가β화정도、결정도화열은정성교교련전균유소증가,능형성은정적분자구상,열은정성유소제고,재조직공정중가위특정세포제공결구지지,유망성위일충신형적조직공정지가재료。
Biocompatible and biodegradable PLCL and PLLA were used as raw material.Through the electrostatic spinning method,with a 70∶30 as mass ratio of SF/COL and PLCL/PLLA blending preparation of nanofiber scaffold materials of different mass ratio.The methods of X-ray diffraction (XRD),thermogravimetric analysis on the physical and chemical properties of the composites were characterized and their performance were dis-cussed and compared before and after cross-linking.Results showed that SF/COL/polymer composite after its molecular structure and thermal stability change was not obvious.Meanwhile,crosslinked composite nanofibers stent beta degree,crystallinity and thermal stability increased before the crosslinking that could form stable conformation,thermal stability,so it could provide structure for certain cells in the tissue engineering support, which was expected to become a new type of tissue engineering scaffold material.