中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2009年
5期
522-523
,共2页
原发性高血压%内皮型一氧化氮合酶基因%关联
原髮性高血壓%內皮型一氧化氮閤酶基因%關聯
원발성고혈압%내피형일양화담합매기인%관련
Essential hypertension%Endothelial nitric oxide synthase gene%Association
采用聚合酶链反应结合聚丙烯酰胺凝胶电泳检测湖北汉族316例原发性高血压患者和338名正常人内皮型一氧化氮合酶(eNOS)基因第4内含子多态性,发现eNOS基因该位点多态性(ab+aa等位基因)与原发性高血压显著相关(P＜0.05),可能是湖北汉族人群原发性高血压的一个易感标记.
採用聚閤酶鏈反應結閤聚丙烯酰胺凝膠電泳檢測湖北漢族316例原髮性高血壓患者和338名正常人內皮型一氧化氮閤酶(eNOS)基因第4內含子多態性,髮現eNOS基因該位點多態性(ab+aa等位基因)與原髮性高血壓顯著相關(P＜0.05),可能是湖北漢族人群原髮性高血壓的一箇易感標記.
채용취합매련반응결합취병희선알응효전영검측호북한족316례원발성고혈압환자화338명정상인내피형일양화담합매(eNOS)기인제4내함자다태성,발현eNOS기인해위점다태성(ab+aa등위기인)여원발성고혈압현저상관(P＜0.05),가능시호북한족인군원발성고혈압적일개역감표기.
The endothelial nitric oxide synthase (eNOS) gene intron 4 polymorphism was determined in 316 cases with essential hypertension and 338 healthy controls using polymerase chain reaction and polyacrylamide gel electrophoresis in Hubei Han Chinese.It was found that the polymorphism (ab + aa heplotype)might be associated with increased risk of essential hypertension(P＜0.05).
