CAJ | 학술논문

疟原虫是人体疟疾的病原体，其在人体内发育可以分为肝内期和红内期。对红内期疟原虫免疫机制的研究表明，疟原虫作为“抗原”侵入人体后，人血清中就会产生能够对抗该疟原虫的免疫活性物质，其中抗体和细胞因子发挥主要的免疫保护作用。抗体具有降低疟疾发病率的作用，然而不同抗原诱导产生的抗体的保护作用强度不同。 Th1和Th2型细胞因子在控制原虫血症、建立抗体介导的抗疟免疫机制、以及多种病理损伤的发生中发挥重要作用。着重就免疫血清中的抗体和细胞因子对红内期疟原虫的免疫作用做一概述。
학원충시인체학질적병원체，기재인체내발육가이분위간내기화홍내기。대홍내기학원충면역궤제적연구표명，학원충작위“항원”침입인체후，인혈청중취회산생능구대항해학원충적면역활성물질，기중항체화세포인자발휘주요적면역보호작용。항체구유강저학질발병솔적작용，연이불동항원유도산생적항체적보호작용강도불동。 Th1화Th2형세포인자재공제원충혈증、건립항체개도적항학면역궤제、이급다충병리손상적발생중발휘중요작용。착중취면역혈청중적항체화세포인자대홍내기학원충적면역작용주일개술。
Plasmodium is the pathogen of human malaria. Its development in the human body can be divided into he-patic stage and blood stage. Study on the immune mechanism of blood stage malaria parasites has shown that after plasmodium as “antigen” invades the human body, the serum will be able to generate immune active substances against the parasites, among them antibodies and cytokines play major role in immune protection. Antibodies could re-duce the incidence of malaria, however, the intensity of protection effects of antibody induced-produced by different antigen is different. Th1 and Th2-type cytokines play an important role in controlling parasitemia and establishing anti-body-mediated immune mechanisms as well as in the happening of multiple patho-traumas. The immunology of anti-body in serum of cytokine against plasmodium in blood-stage was focused in this summary.