南昌大学学报（理科版）
南昌大學學報（理科版）
남창대학학보（이과판）
JOURNAL OF NANCHANG UNIVERSITY(NATURAL SCIENCE)
2013年
6期
577-580
,共4页
陈蒜提取物%6-OHDA%黑质多巴胺能神经元凋亡%核转录因子κB核转位
陳蒜提取物%6-OHDA%黑質多巴胺能神經元凋亡%覈轉錄因子κB覈轉位
진산제취물%6-OHDA%흑질다파알능신경원조망%핵전록인자κB핵전위
Aged Garlic Extract%6-OHDA%Apoptosis of dopaminergic neurons%Nuclear transcription factorκB
以6-羟基多巴（6-OHDA）建立帕金森病（PD）模型大鼠，研究陈蒜提取物对模型大鼠黑质多巴胺能神经元凋亡以及核转录因子κB（NF-κB）核转位的影响。实验大鼠分别给予低、中、高剂量陈蒜提取物，观察大鼠行为变化与阿朴吗啡诱导的旋转运动，并采用免疫组化技术检测实验大鼠黑质多巴胺神经元的酪氨酸羟化酶（TH）和 NF-κB表达情况。结果显示，陈蒜提取物能显著抑制阿朴吗啡诱导的模型大鼠旋转，可抑制黑质多巴胺能神经元的损伤与 NF-κB的核转位。推测陈蒜提取物抑制黑质神经元凋亡的机理与抑制 NF-κB的激活有关。
以6-羥基多巴（6-OHDA）建立帕金森病（PD）模型大鼠，研究陳蒜提取物對模型大鼠黑質多巴胺能神經元凋亡以及覈轉錄因子κB（NF-κB）覈轉位的影響。實驗大鼠分彆給予低、中、高劑量陳蒜提取物，觀察大鼠行為變化與阿樸嗎啡誘導的鏇轉運動，併採用免疫組化技術檢測實驗大鼠黑質多巴胺神經元的酪氨痠羥化酶（TH）和 NF-κB錶達情況。結果顯示，陳蒜提取物能顯著抑製阿樸嗎啡誘導的模型大鼠鏇轉，可抑製黑質多巴胺能神經元的損傷與 NF-κB的覈轉位。推測陳蒜提取物抑製黑質神經元凋亡的機理與抑製 NF-κB的激活有關。
이6-간기다파（6-OHDA）건립파금삼병（PD）모형대서，연구진산제취물대모형대서흑질다파알능신경원조망이급핵전록인자κB（NF-κB）핵전위적영향。실험대서분별급여저、중、고제량진산제취물，관찰대서행위변화여아박마배유도적선전운동，병채용면역조화기술검측실험대서흑질다파알신경원적락안산간화매（TH）화 NF-κB표체정황。결과현시，진산제취물능현저억제아박마배유도적모형대서선전，가억제흑질다파알능신경원적손상여 NF-κB적핵전위。추측진산제취물억제흑질신경원조망적궤리여억제 NF-κB적격활유관。
According to the Parkinson disease model of rat substantia nigra built by 6-OHDA,the effects of aged garlic extract on the activation of (nuclear transcription factorκB)NF-кB and apoptosis of dopaminer-gic neurons were studied.These rats were given low,medium and high doses of aged garlic extract,and ap-omorphine-induced rotational behavior in these rats were observed.The expression levels of tyrosine hydroxylase (TH )and NF-kB from rat substantia nigra were examined by using immunohistochemical technology.The results showed that rotational behavior,nuclear translocation of NF-κB and damage of do-paminergic neurons in these rats were significantly inhibited by aged garlic extract.Terefore,it is specula-ted that the mechanism on aged garlic extract inhibiting apotosis in substantia nigra neurons may be con-cerned with inhibiting the activation of NF-κB.
