CAJ | 학술논문

目的：研究中西药复方蛇脂清癣软膏对真菌感染动物的治疗作用及抗炎作用。方法：采用红色毛癣菌和羊毛状小孢子菌感染的豚鼠模型，观察硝酸咪康唑与蛇油、苦参等中药合用制成的蛇脂清癣软膏（SZQX软膏）经皮肤给药后的抗真菌感染作用；并同时观察其对巴豆油所致小鼠耳肿胀、角叉菜胶诱发大鼠足肿胀的影响。结果：SZQX软膏对红色毛癣菌和羊毛状小孢子菌分别感染的豚鼠有保护作用，可明显降低感染豚鼠局部皮损的镜检评分（P<0.01），效果优于中西药单独运用；SZQX软膏还能显著减轻巴豆油致小鼠耳肿胀程度、减轻角叉菜胶诱发的大鼠足肿胀程度（P<0.05或P<0.01），具有明显的抗炎作用，且优于中、西药单独运用。结论：SZQX软膏具有明显的抗真菌感染及抗炎作用。
목적：연구중서약복방사지청선연고대진균감염동물적치료작용급항염작용。방법：채용홍색모선균화양모상소포자균감염적돈서모형，관찰초산미강서여사유、고삼등중약합용제성적사지청선연고（SZQX연고）경피부급약후적항진균감염작용；병동시관찰기대파두유소치소서이종창、각차채효유발대서족종창적영향。결과：SZQX연고대홍색모선균화양모상소포자균분별감염적돈서유보호작용，가명현강저감염돈서국부피손적경검평분（P<0.01），효과우우중서약단독운용；SZQX연고환능현저감경파두유치소서이종창정도、감경각차채효유발적대서족종창정도（P<0.05혹P<0.01），구유명현적항염작용，차우우중、서약단독운용。결론：SZQX연고구유명현적항진균감염급항염작용。
This article was aimed to study the therapeutic effects and anti-inflammatory effects of Chinese and west-ern medicine ointment on fungal infection animals. Guinea pig models which were infected with Trichophyton rubrum or Microsporum lanosum were applied to observe the effects of antifungal infections on She-Zhi Qin-Xian (SZQX) ointment by transdermal administration. The ointment is the combination of miconazole nitrate, snake oil and Sophora flavescens which is traditional Chinese medicine (TCM). Simultaneously, the models of croton oil-induced mouse ear swelling and carrageenan-induced rat paw swelling were established to observe the curative effect of SZQX ointment. The results showed that the SZQX ointment had a protective role on both guinea pig models. The microscopic scale of localized lesions in infected guinea pigs was significantly decreased (P< 0.01). The effect of SZQX ointment was better than the single using of Chinese or western medicine. The SZQX ointment was also able to significantly reduce the croton oil-induced mouse ear swelling and carrageenan-induced rat paw swelling (P< 0.05, or P< 0.01) with distinct anti-inflammatory effect. And the effect of SZQX ointment was superior to the single using of either Chinese or western medicine. It was concluded that the SZQX ointment had significant antifungal infection and anti-inflam-matory effect.