CAJ | 학술논문

目的：观察对药酸枣仁-合欢花对老年抑郁症患者生活质量的影响。方法：收集老年抑郁症病例70例，随机分为中药组和西药组，各35例。中药组服用酸枣仁-合欢花汤剂；西药组服用盐酸文拉法辛缓释片。两组分别于治疗前及治疗8周后进行HAMD抑郁量表、生活质量综合评定问卷（GQOLI-74）和副作用量表（TESS）评分。结果：治疗后两组间临床疗效无显著差异；生活质量综合评定方面：中药组患者躯体功能维度、心理功能维度及生活质量总分高于西药组，差异有统计学意义（P<0.05）。物质生活维度、社会功能维度与西药组无显著差异；治疗后两组患者的HAMD评分、躯体功能维度、心理功能维度、社会功能维度、生活质量总分均高于治疗前，差异均有统计学意义（P<0.05）。中药组TESS评分低于西药组，其不良反应主要为恶心呕吐。结论：酸枣仁-合欢花汤剂具有抗抑郁功效，能够改善老年抑郁患者的生活质量。
목적：관찰대약산조인-합환화대노년억욱증환자생활질량적영향。방법：수집노년억욱증병례70례，수궤분위중약조화서약조，각35례。중약조복용산조인-합환화탕제；서약조복용염산문랍법신완석편。량조분별우치료전급치료8주후진행HAMD억욱량표、생활질량종합평정문권（GQOLI-74）화부작용량표（TESS）평분。결과：치료후량조간림상료효무현저차이；생활질량종합평정방면：중약조환자구체공능유도、심리공능유도급생활질량총분고우서약조，차이유통계학의의（P<0.05）。물질생활유도、사회공능유도여서약조무현저차이；치료후량조환자적HAMD평분、구체공능유도、심리공능유도、사회공능유도、생활질량총분균고우치료전，차이균유통계학의의（P<0.05）。중약조TESS평분저우서약조，기불량반응주요위악심구토。결론：산조인-합환화탕제구유항억욱공효，능구개선노년억욱환자적생활질량。
This study was aimed to observe the effects of herbal pair of Semen ziziphi spinosae (SZS) and A lbizia julibrissin flower (AJF) on the quality of life (QOL) among elderly patients with depression. A total of 70 elderly patients with depression were enrolled and randomly divided into two groups. The Chinese medicine group (with 35 cases) was given SZS-AJF decoction, and the western medicine group (with 35 cases) was given venlafaxine hydrochloride sustained-release tablets. The HAMD scale score, QOL Assessment Questionnaire (GQOLI-74), and the Side-Effects Scale Score (TESS) were detected 8 weeks before and after the treatment. The results showed that there was no significant difference on the clinical efficacy between two groups. On the comprehensive assessment of QOL, the physical function dimension, mental function dimension and QOL total score of Chinese medicine group were higher than the western medicine group with significant difference (P < 0.05). There were no significant differences on the material function dimension or social function dimensions between two groups. The HAMD score, physical function dimension, mental function dimension, social function dimension and score of QOL were all higher than the pretreatment score with significant differences in both groups (P < 0.05). The TESS score in Chinese medicine group was lower than the western medicine group. And the main adverse reactions in the Chinese medicines group were nausea and vomiting. It was concluded that the herbal pair of SZS and AJF had antidepressant efficacy. It can improve the QOL among elderly patients with depression.