医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2014年
1期
21-22,57
,共3页
唐氏综合征%产期筛查%PAPP-A%AFP%β-HCG
唐氏綜閤徵%產期篩查%PAPP-A%AFP%β-HCG
당씨종합정%산기사사%PAPP-A%AFP%β-HCG
Down syndrome%Prenatal screening%PAPP-A%AFP%β-HCG
目的：探讨唐氏综合征产前筛查的应用价值。方法：采用罗氏化学发光法对596例孕妇孕早期（一期）开展妊娠相关蛋白A（PAPP-A）和游离β人绒毛膜促性腺激素（Freeβ-HCG），孕中期（二期）项目开展甲胎蛋白（AFP）和β人绒毛膜促性腺激素（β-HCG）的筛查，对高风险孕妇行羊水胎儿细胞染色体核型分析，并给予确诊。随访直至产后2个月。结果：596例患者进行筛查，一期筛查中出现15例唐氏综合征高风险孕妇，二期筛查中出现27例高风险孕妇，其中包括一期筛查中的13例。在29例唐氏综合征高风险孕妇中，35岁以上者18例，确诊1例，随访至产后2个月，其他所有患者均未见唐氏综合征患儿，检出率为100%。结论：在不同孕期分别开展唐氏综合征的产前筛查及诊断，筛出率高，可有效避免缺陷胎儿的出生。
目的：探討唐氏綜閤徵產前篩查的應用價值。方法：採用囉氏化學髮光法對596例孕婦孕早期（一期）開展妊娠相關蛋白A（PAPP-A）和遊離β人絨毛膜促性腺激素（Freeβ-HCG），孕中期（二期）項目開展甲胎蛋白（AFP）和β人絨毛膜促性腺激素（β-HCG）的篩查，對高風險孕婦行羊水胎兒細胞染色體覈型分析，併給予確診。隨訪直至產後2箇月。結果：596例患者進行篩查，一期篩查中齣現15例唐氏綜閤徵高風險孕婦，二期篩查中齣現27例高風險孕婦，其中包括一期篩查中的13例。在29例唐氏綜閤徵高風險孕婦中，35歲以上者18例，確診1例，隨訪至產後2箇月，其他所有患者均未見唐氏綜閤徵患兒，檢齣率為100%。結論：在不同孕期分彆開展唐氏綜閤徵的產前篩查及診斷，篩齣率高，可有效避免缺陷胎兒的齣生。
목적：탐토당씨종합정산전사사적응용개치。방법：채용라씨화학발광법대596례잉부잉조기（일기）개전임신상관단백A（PAPP-A）화유리β인융모막촉성선격소（Freeβ-HCG），잉중기（이기）항목개전갑태단백（AFP）화β인융모막촉성선격소（β-HCG）적사사，대고풍험잉부행양수태인세포염색체핵형분석，병급여학진。수방직지산후2개월。결과：596례환자진행사사，일기사사중출현15례당씨종합정고풍험잉부，이기사사중출현27례고풍험잉부，기중포괄일기사사중적13례。재29례당씨종합정고풍험잉부중，35세이상자18례，학진1례，수방지산후2개월，기타소유환자균미견당씨종합정환인，검출솔위100%。결론：재불동잉기분별개전당씨종합정적산전사사급진단，사출솔고，가유효피면결함태인적출생。
Objective:To Maternal serum marker in fetal Down 's syndrome prenatal screening application value. Methods:Using the Roche chemiluminescence method in 596 cases of pregnant women in early pregnancy of pregnancy associated plasma protein A and free beta human chorionic gonadotropin, the second trimester to carry out the project of alpha-fetoprotein and beta human chorionic gonadotropin screening for high risk pregnant women, amniotic fluid and fetal cells karyotype analysis, and give diagnosis. The patients were followed up until 2 months postpartum.Results:In 596 patients undergoing screening, screening for a period in15 cases of Down syndrome screening in high risk pregnant women, two in27 cases of high risk pregnant women, including a screening in 13cases. In 29 cases of Down's syndrome in high risk pregnant women over the age of 35, in 18 cases, diagnosed in 1 patients, followed up to2 months postpartum, all other patients are seen in children with Down's syndrome, the detection rate is 100%. Conclusions:At different stages of gestation respectively in Down's syndrome prenatal screening and diagnosis, screening out rate is high, which can effectively avoid the defect of fetal birth.
