中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2013年
5期
187-188
,共2页
急性冠状动脉综合征%淋巴毒素-α
急性冠狀動脈綜閤徵%淋巴毒素-α
급성관상동맥종합정%림파독소-α
acute coronary syndrome%Lymphotoxin alpha
目的：检测急性冠状动脉综合征（ACS）患者血清淋巴毒素-α（LTA）水平，探讨其在不同类型ACS患者血清浓度变化及其在ACS发生、发展中的作用。方法：将74例ACS患者分为ST段抬高型ACS 35例，非ST段抬高型ACS 39例，另取13例冠状动脉造影（CAG）结果正常者作为对照。采用Elisa法测定各组血清LTA浓度并分别进行比较。结果：ST段抬高型ACS（ST-ACS）患者组血清LTA浓度高于非ST段抬高型ACS（NST-ACS）患者组（204.54±125.17 ng/ml vs 128.40±66.11 ng/ml，P<0.05），ST-ACS患者组血清LTA浓度高于CAG正常组（204.54±125.17 ng/ml vs 43.01±35.06 ng/ml，P<0.01）、NST-ACS组患者血清LTA浓度高于CAG正常组（128.40±66.11 ng/ml vs 43.01±35.06 ng/ml，P<0.01）。三组两两比较差异均有统计学意义。结论：LTA可能促进ACS患者冠状动脉粥样硬化斑块破裂与血栓形成。
目的：檢測急性冠狀動脈綜閤徵（ACS）患者血清淋巴毒素-α（LTA）水平，探討其在不同類型ACS患者血清濃度變化及其在ACS髮生、髮展中的作用。方法：將74例ACS患者分為ST段抬高型ACS 35例，非ST段抬高型ACS 39例，另取13例冠狀動脈造影（CAG）結果正常者作為對照。採用Elisa法測定各組血清LTA濃度併分彆進行比較。結果：ST段抬高型ACS（ST-ACS）患者組血清LTA濃度高于非ST段抬高型ACS（NST-ACS）患者組（204.54±125.17 ng/ml vs 128.40±66.11 ng/ml，P<0.05），ST-ACS患者組血清LTA濃度高于CAG正常組（204.54±125.17 ng/ml vs 43.01±35.06 ng/ml，P<0.01）、NST-ACS組患者血清LTA濃度高于CAG正常組（128.40±66.11 ng/ml vs 43.01±35.06 ng/ml，P<0.01）。三組兩兩比較差異均有統計學意義。結論：LTA可能促進ACS患者冠狀動脈粥樣硬化斑塊破裂與血栓形成。
목적：검측급성관상동맥종합정（ACS）환자혈청림파독소-α（LTA）수평，탐토기재불동류형ACS환자혈청농도변화급기재ACS발생、발전중적작용。방법：장74례ACS환자분위ST단태고형ACS 35례，비ST단태고형ACS 39례，령취13례관상동맥조영（CAG）결과정상자작위대조。채용Elisa법측정각조혈청LTA농도병분별진행비교。결과：ST단태고형ACS（ST-ACS）환자조혈청LTA농도고우비ST단태고형ACS（NST-ACS）환자조（204.54±125.17 ng/ml vs 128.40±66.11 ng/ml，P<0.05），ST-ACS환자조혈청LTA농도고우CAG정상조（204.54±125.17 ng/ml vs 43.01±35.06 ng/ml，P<0.01）、NST-ACS조환자혈청LTA농도고우CAG정상조（128.40±66.11 ng/ml vs 43.01±35.06 ng/ml，P<0.01）。삼조량량비교차이균유통계학의의。결론：LTA가능촉진ACS환자관상동맥죽양경화반괴파렬여혈전형성。
Objective:To investigate the change of Lymphotoxin alpha(LTA) in the patients with acute coronary syndrome (ACS),and to explore its contribution in the development of ACS . Methods:Seventy-four patients with diagnosed ACS through coronary angiography(CAG) were divided into 35 cases of ST elevation myocardial infraction(STEMI), 39 cases of non-ST elevation myocardial infraction(STEMI) and 13 cases of normal angiography serves as control group. The serum concentrations of LTA in the patients with ACS was detected with enzyme linked immunosorbent assay way. Results:The concentrations of LTA in the patients with ST-ACS group were higher than in the patients with NST-ACS group(204.54±125.17 ng/ml vs 128.40±66.11 ng/ml ,p<0.05), The concentrations of LTA in the patients with ST- ACS group were higher than the normal group(204.54±125.17 ng/ml vs 43.01±35.06 ng/ml, p<0.01 ) ,The concentrations of LTA in the patients with NST-ACS group was higher than the normal group(128.40±66.11 ng/ml vs 43.01±35.06 ng/ml, p<0.01 ), Three sets of pairwise comparisons were statistical y significant .Conclusion:LTA may promote coronary atherosclerotic plaque rupture and thrombosis in the patients with ACS.
