医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2014年
1期
12-14
,共3页
血清铁蛋白%游离脂肪酸%妊娠期糖尿病%胰岛素抵抗
血清鐵蛋白%遊離脂肪痠%妊娠期糖尿病%胰島素牴抗
혈청철단백%유리지방산%임신기당뇨병%이도소저항
Serum ferritin(SF)%Free fatty acid(FFA)%Gestational diabetes(GDM)%Insulin resistance(IR)
目的:探讨血清铁蛋白(SF)及游离脂肪酸(FFA)与妊娠期糖尿病(GDM)患者胰岛素抵抗(IR)的关系,为早期干预GDM的发生发展提供依据。方法:2011年1月至2013年10月,以同期GDM组(71例)、正常孕妇组(50例)及正常非孕组(50例)为研究对象。同时检测空腹血清SF(电化学发光免疫法)、FFA(酶联法)、血糖(FBG)及胰岛素(Fins)水平[FBG,Fins,计算胰岛素抵抗指数(HOMA-IR)值],并进行统计学分析。结果:正常非孕组、正常孕妇组及GDM组,三组血清SF水平(119.57±22.04,197.81±46.32,388.79±91.67)依次升高,且相差显著(F=57.543,P<0.01),GDM组显著高于正常孕妇组(t=9.826,P<0.01);三组血清FFA水平(0..43±0.18,0.67±0.14,1.03±0.21)依次升高,且相差显著(F=37.619,P<0.01),GDM组显著高于正常孕妇组(t=6.004,P<0.01);三组HOMA-IR值(1.83±0.45,2.92±0.87,3.94±1.02)依次升高,且相差显著(F=45.071,P<0.01),GDM组显著高于正常孕妇组(t=11.183,P<0.01)。GDM患者空腹血清SF、FFA水平分别与HOMA-IR值呈显著正相关(r=0.832、0.759,P<0.01),空腹血清FFA水平与SF水平也呈显著正相关(r=0.893,P<0.01),其相关性良好。结论:妊娠期糖尿病患者体内存在着高铁蛋白、游离脂肪酸血症及胰岛素抵抗状态,血清铁蛋白和游离脂肪酸水平与胰岛素抵抗相关,此为早期干预妊娠期糖尿病的发生发展提供了理论依据。
目的:探討血清鐵蛋白(SF)及遊離脂肪痠(FFA)與妊娠期糖尿病(GDM)患者胰島素牴抗(IR)的關繫,為早期榦預GDM的髮生髮展提供依據。方法:2011年1月至2013年10月,以同期GDM組(71例)、正常孕婦組(50例)及正常非孕組(50例)為研究對象。同時檢測空腹血清SF(電化學髮光免疫法)、FFA(酶聯法)、血糖(FBG)及胰島素(Fins)水平[FBG,Fins,計算胰島素牴抗指數(HOMA-IR)值],併進行統計學分析。結果:正常非孕組、正常孕婦組及GDM組,三組血清SF水平(119.57±22.04,197.81±46.32,388.79±91.67)依次升高,且相差顯著(F=57.543,P<0.01),GDM組顯著高于正常孕婦組(t=9.826,P<0.01);三組血清FFA水平(0..43±0.18,0.67±0.14,1.03±0.21)依次升高,且相差顯著(F=37.619,P<0.01),GDM組顯著高于正常孕婦組(t=6.004,P<0.01);三組HOMA-IR值(1.83±0.45,2.92±0.87,3.94±1.02)依次升高,且相差顯著(F=45.071,P<0.01),GDM組顯著高于正常孕婦組(t=11.183,P<0.01)。GDM患者空腹血清SF、FFA水平分彆與HOMA-IR值呈顯著正相關(r=0.832、0.759,P<0.01),空腹血清FFA水平與SF水平也呈顯著正相關(r=0.893,P<0.01),其相關性良好。結論:妊娠期糖尿病患者體內存在著高鐵蛋白、遊離脂肪痠血癥及胰島素牴抗狀態,血清鐵蛋白和遊離脂肪痠水平與胰島素牴抗相關,此為早期榦預妊娠期糖尿病的髮生髮展提供瞭理論依據。
목적:탐토혈청철단백(SF)급유리지방산(FFA)여임신기당뇨병(GDM)환자이도소저항(IR)적관계,위조기간예GDM적발생발전제공의거。방법:2011년1월지2013년10월,이동기GDM조(71례)、정상잉부조(50례)급정상비잉조(50례)위연구대상。동시검측공복혈청SF(전화학발광면역법)、FFA(매련법)、혈당(FBG)급이도소(Fins)수평[FBG,Fins,계산이도소저항지수(HOMA-IR)치],병진행통계학분석。결과:정상비잉조、정상잉부조급GDM조,삼조혈청SF수평(119.57±22.04,197.81±46.32,388.79±91.67)의차승고,차상차현저(F=57.543,P<0.01),GDM조현저고우정상잉부조(t=9.826,P<0.01);삼조혈청FFA수평(0..43±0.18,0.67±0.14,1.03±0.21)의차승고,차상차현저(F=37.619,P<0.01),GDM조현저고우정상잉부조(t=6.004,P<0.01);삼조HOMA-IR치(1.83±0.45,2.92±0.87,3.94±1.02)의차승고,차상차현저(F=45.071,P<0.01),GDM조현저고우정상잉부조(t=11.183,P<0.01)。GDM환자공복혈청SF、FFA수평분별여HOMA-IR치정현저정상관(r=0.832、0.759,P<0.01),공복혈청FFA수평여SF수평야정현저정상관(r=0.893,P<0.01),기상관성량호。결론:임신기당뇨병환자체내존재착고철단백、유리지방산혈증급이도소저항상태,혈청철단백화유리지방산수평여이도소저항상관,차위조기간예임신기당뇨병적발생발전제공료이론의거。
Objective:Explore serum ferritin(SF) and free fatty acid(FFA) patients with gestational diabetes mellitus(GDM) the relationship between insulin resistance(IR), provide the basis for early intervention of GDM development. Methods:Between January 2011 to October 2013, with the same period the GDM group (71 cases) and normal pregnant woman group (50 cases) and normal non pregnant group (50 cases) as the research object. Fasting serum SF and FFA level detection by electrochemiluminescence immunoassay and enzyme-linked method respectively, while detecting FBG and the level of Fins, HOMA-IR was calculated, and statistical analysis.Results:Normal non pregnant group and the normal pregnant women and GDM group,three groups of serum SF levels (119.57±22.04,197.81±46.32,388.79±91.67), in turn, increases, and differ significantly (F=57.543,P<0.01), the GDM group is significantly higher than normal pregnant women (t=9.826,P < 0.01). Three groups of serum FFA levels (0..43±0.18, 0.67±0.14,1.03±0.21), in turn, increases, and differ significantly (F=37.619,P<0.01), the GDM group is significantly higher than normal pregnant women (t=6.004,P<0.01).Three groups of HOMA-IR values (1.83±0.45,2.92±0.87,3.94±1.02), in turn, increases, and differ significantly (F=45.071,P<0.01), the GDM group is significantly higher than normal pregnant women (t=11.183, P < 0.01). GDM patients fasting serum SF, FFA levels respectively was inersely associated with HOMA-IR value has significant positive correlation (r=0.832、0.759,P<0.01), fasting serum FFA levels and SF levels also has significant positive correlation (r=0.893, P<0.01), the correlation is good. Conclusions:GDM patients has high SF and FFA concentration and IR state, SF and FFA levels associated with IR, this for early intervention of GDM development provides a theoretical basis.