CAJ | 학술논문

以除草剂丁草胺溶液为染毒药物，以小鼠为实验对象，利用Morris水迷宫系统研究了丁草胺对小鼠的急性致死效应和空间记忆能力的影响.实验结果表明：丁草胺对小鼠的LD50为22.74 mg/kg（95%的置信区间为15.17～34.52 mg/kg）.除个别低剂量处理组外，大部分的丁草胺处理组的平均潜伏逃避时间、平均游泳距离都明显长于空白对照组，而且均达到了差异显著水平（P<0.05）或差异极显著水平（P<0.01或P<0.001）.实验还发现不同的入水次序和入水象限对小鼠的空间记忆能力有较大的影响.在第1象限（目标象限）入水和第4入水次序时，小鼠的平均逃避潜伏时间和平均游泳距离均较短.
이제초제정초알용액위염독약물，이소서위실험대상，이용Morris수미궁계통연구료정초알대소서적급성치사효응화공간기억능력적영향.실험결과표명：정초알대소서적LD50위22.74 mg/kg（95%적치신구간위15.17～34.52 mg/kg）.제개별저제량처리조외，대부분적정초알처리조적평균잠복도피시간、평균유영거리도명현장우공백대조조，이차균체도료차이현저수평（P<0.05）혹차이겁현저수평（P<0.01혹P<0.001）.실험환발현불동적입수차서화입수상한대소서적공간기억능력유교대적영향.재제1상한（목표상한）입수화제4입수차서시，소서적평균도피잠복시간화평균유영거리균교단.
The pesticide(Butachlor) solution was taken as the target poison and mouse was taken as the experimental animal. The effects of Butachlor on lethal effect and spatial memory in mice were studied. The results showed that the LD50 of Butachlor on mouse was 22.74 mg/kg(the 95% Confidence Limits were 15.17~34.52 mg/kg). The average escape latency times and average swimming distances of every groups that were treated with Butachlor except few groups treated with lowest dose Butachlor were longer than the contrast groups. And there were signifi-cant difference between the experimental groups and contrast group(P<0.05 or P<0.01 or P<0.001). We also found that average escape latency and the average swimming distance were affected strongly by the different test orders and different test quadrants of dropping into the water. In the first quadrant(target quadrant) or the fourth order, the average escape latency and the average swimming distance were less than other quadrants or orders.