CAJ | 학술논문

建立了离子色谱法测定羟乙基淀粉130/0.4醋酸钠林格注射液中Ac-、Cl-、Na+、K+、Mg2+和Ca2+离子的方法。将羟乙基淀粉130/0.4醋酸钠林格注射液样品稀释一定倍数后分别直接进样分析，利用优化的实验条件，6种离子的检出限（S/N=3）为0.9μg/L~6.1μg/L，线性范围跨越两个数量级以上，连续6次进样RSD值小于0.54%，加标回收率为98.88%102.09%，可以给实际羟乙基淀粉130/0.4醋酸钠林格注射液生产线提供可靠的产品质量检测数据。
건립료리자색보법측정간을기정분130/0.4작산납림격주사액중Ac-、Cl-、Na+、K+、Mg2+화Ca2+리자적방법。장간을기정분130/0.4작산납림격주사액양품희석일정배수후분별직접진양분석，이용우화적실험조건，6충리자적검출한（S/N=3）위0.9μg/L~6.1μg/L，선성범위과월량개수량급이상，련속6차진양RSD치소우0.54%，가표회수솔위98.88%102.09%，가이급실제간을기정분130/0.4작산납림격주사액생산선제공가고적산품질량검측수거。
The method to determine Ac-, Cl-, Na+, K+, Mg2+and Ca2+in hydroxyethyl starch 130/0.4 sodium acetate ringer's injection by ion chromatography was proposed. Liquid samles are directly injected into IC by separate diluting. Under optimizing experimental condition, the detection limits are from 0.9μg/L to 6.1μg/L, with recovery in the range of 98.88%102.09%. It may calibrate over two orders of magnitute in concentration of 6 ions while RSD are below 0.54%. Our report can provide credible data of product quality for hydroxyethyl starch 130/0.4 sodium acetate ringer's injection product line.