中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
3期
279-284
,共6页
龙曼%陈爱华%邓敏峰%赖文文%梁艺海
龍曼%陳愛華%鄧敏峰%賴文文%樑藝海
룡만%진애화%산민봉%뢰문문%량예해
妊娠相关蛋白A%急性冠脉综合征%预后%Meta分析
妊娠相關蛋白A%急性冠脈綜閤徵%預後%Meta分析
임신상관단백A%급성관맥종합정%예후%Meta분석
Pregnancy-associated plasma protein-A%Acute coronary syndrome%Prognosis%Meta-analysis
目的 定量评价妊娠相关蛋白A对急性冠脉综合征患者未来不良心血管事件发生的预测作用.方法 检索PubMed 、EMBASE 、OVID 、Web of Knowledge和Cochrane Library数据库并手工检索相关参考文献.采用随机效应模型,RR值为效应指标合并妊娠相关蛋白A在急性冠脉综合征预后的相关研究,进行亚组分析识别异质性的来源.结果 纳入14篇文献共9413例急性冠脉综合征患者,合并RR值及其95％CI为1.97(1.49 ～ 2.60),提示妊娠相关蛋白A可预测急性冠脉综合征患者的预后.研究设计类型、风险效应指标值的选用及随访时间的长短是异质性的主要来源.结论 妊娠相关蛋白A是评价急性冠脉综合征患者预后的有效指标,即患者早期血浆妊娠相关蛋白A水平升高预示未来不良心血管事件发生的风险增加.
目的 定量評價妊娠相關蛋白A對急性冠脈綜閤徵患者未來不良心血管事件髮生的預測作用.方法 檢索PubMed 、EMBASE 、OVID 、Web of Knowledge和Cochrane Library數據庫併手工檢索相關參攷文獻.採用隨機效應模型,RR值為效應指標閤併妊娠相關蛋白A在急性冠脈綜閤徵預後的相關研究,進行亞組分析識彆異質性的來源.結果 納入14篇文獻共9413例急性冠脈綜閤徵患者,閤併RR值及其95％CI為1.97(1.49 ～ 2.60),提示妊娠相關蛋白A可預測急性冠脈綜閤徵患者的預後.研究設計類型、風險效應指標值的選用及隨訪時間的長短是異質性的主要來源.結論 妊娠相關蛋白A是評價急性冠脈綜閤徵患者預後的有效指標,即患者早期血漿妊娠相關蛋白A水平升高預示未來不良心血管事件髮生的風險增加.
목적 정량평개임신상관단백A대급성관맥종합정환자미래불양심혈관사건발생적예측작용.방법 검색PubMed 、EMBASE 、OVID 、Web of Knowledge화Cochrane Library수거고병수공검색상관삼고문헌.채용수궤효응모형,RR치위효응지표합병임신상관단백A재급성관맥종합정예후적상관연구,진행아조분석식별이질성적래원.결과 납입14편문헌공9413례급성관맥종합정환자,합병RR치급기95％CI위1.97(1.49 ～ 2.60),제시임신상관단백A가예측급성관맥종합정환자적예후.연구설계류형、풍험효응지표치적선용급수방시간적장단시이질성적주요래원.결론 임신상관단백A시평개급성관맥종합정환자예후적유효지표,즉환자조기혈장임신상관단백A수평승고예시미래불양심혈관사건발생적풍험증가.
Objective To evaluate the overall prognostic effects of pregnancy-associated plasma protein-A (PAPP-A) in acute coronary syndrome (ACS)through a meta-analysis.Methods Literature was retrieved by formal searching of electronic databases (PubMed,EMBASE,OVID,Web of Knowledge,and the Cochrane Library) and by hand searching of reference lists of related articles.Random effects meta-analysis and relative risk were used to estimate the association between PAPP-A levels and adverse cardiovascular outcomes after ACS as well as preplanned subgroup analyses were conducted to identify the risk-subgroup interactions that could explain the between differences.Results A total of fourteen clinical trials were included in this Meta-analysis which involving 9413 patients.Pooled RR and their 95％ confidence intervals (CIs) for all eligible studies was 1.97 (1.49-2.60),which indicated a prognostic value of PAPP-A in patients with ACS.Differences in study design,measurement of association and duration of follow-up were responsible for the differences in results across the studies.Conclusion Our results suggested that a higher early blood PAPP-A could moderately increase the long-term risk of adverse cardiovascular outcomes and might serve as a valuable prognostic predictor in patients with ACS.
