医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
9期
88-88,89
,共2页
孙蓓蓓%封东进%张锐锋%王光猛
孫蓓蓓%封東進%張銳鋒%王光猛
손배배%봉동진%장예봉%왕광맹
熊去氧胆酸%茵栀黄口服液%婴儿肝炎综合征
熊去氧膽痠%茵梔黃口服液%嬰兒肝炎綜閤徵
웅거양담산%인치황구복액%영인간염종합정
Ursodeoxycholic Acid%Yinzhihuang oral liquid%Infantile hepatitis syndrome
目的：探讨熊去氧胆酸(ursodeoxycholic acid ，UDCA)联合茵栀黄口服液治疗婴儿肝炎综合征(IHS)的疗效。方法46例IHS患儿随机分为治疗组26例(男17例，女9例；平均年龄2.35个月)与对照组20例(男10例，女10例；平均年龄2.05个月)。两组病例均予美能降转氨酶及基础治疗。对照组单用茵栀黄口服液退黄治疗，治疗组在此基础上加用UDCA 10~25 mg/Kg/d，分2次服用，连续应用14 d为1个疗程，部分用2疗程。监测两组患儿治疗前后血清总胆红素(TB)、结合胆红素(DB)、谷丙转氨酶（ALT）、γ-谷氨酰转肽酶(γ-GT)、总胆汁酸(TBA)水平。结果与治疗前比较，治疗后各组患儿血清及胆汁中 TB、DB、ALT、γ-GT、TBA均显著降低，差异有统计学意义(P<0.01)。治疗后，与对照组比较，治疗组血清TB、DB、γ-GT、TBA均有明显下降，差异有显著性(P<0.05)，血清 ALT升高，差异有统计学意义(P<0.05)。与对照组比较，治疗组的总有效率升高，差异有统计学意义(P<0.05)。结论 UDCA联合茵栀黄口服液能降低血清胆红素及内源性胆汁酸水平，可促进胆红素、TBA排泄，具有明显的利胆、退黄的疗效。
目的：探討熊去氧膽痠(ursodeoxycholic acid ，UDCA)聯閤茵梔黃口服液治療嬰兒肝炎綜閤徵(IHS)的療效。方法46例IHS患兒隨機分為治療組26例(男17例，女9例；平均年齡2.35箇月)與對照組20例(男10例，女10例；平均年齡2.05箇月)。兩組病例均予美能降轉氨酶及基礎治療。對照組單用茵梔黃口服液退黃治療，治療組在此基礎上加用UDCA 10~25 mg/Kg/d，分2次服用，連續應用14 d為1箇療程，部分用2療程。鑑測兩組患兒治療前後血清總膽紅素(TB)、結閤膽紅素(DB)、穀丙轉氨酶（ALT）、γ-穀氨酰轉肽酶(γ-GT)、總膽汁痠(TBA)水平。結果與治療前比較，治療後各組患兒血清及膽汁中 TB、DB、ALT、γ-GT、TBA均顯著降低，差異有統計學意義(P<0.01)。治療後，與對照組比較，治療組血清TB、DB、γ-GT、TBA均有明顯下降，差異有顯著性(P<0.05)，血清 ALT升高，差異有統計學意義(P<0.05)。與對照組比較，治療組的總有效率升高，差異有統計學意義(P<0.05)。結論 UDCA聯閤茵梔黃口服液能降低血清膽紅素及內源性膽汁痠水平，可促進膽紅素、TBA排洩，具有明顯的利膽、退黃的療效。
목적：탐토웅거양담산(ursodeoxycholic acid ，UDCA)연합인치황구복액치료영인간염종합정(IHS)적료효。방법46례IHS환인수궤분위치료조26례(남17례，녀9례；평균년령2.35개월)여대조조20례(남10례，녀10례；평균년령2.05개월)。량조병례균여미능강전안매급기출치료。대조조단용인치황구복액퇴황치료，치료조재차기출상가용UDCA 10~25 mg/Kg/d，분2차복용，련속응용14 d위1개료정，부분용2료정。감측량조환인치료전후혈청총담홍소(TB)、결합담홍소(DB)、곡병전안매（ALT）、γ-곡안선전태매(γ-GT)、총담즙산(TBA)수평。결과여치료전비교，치료후각조환인혈청급담즙중 TB、DB、ALT、γ-GT、TBA균현저강저，차이유통계학의의(P<0.01)。치료후，여대조조비교，치료조혈청TB、DB、γ-GT、TBA균유명현하강，차이유현저성(P<0.05)，혈청 ALT승고，차이유통계학의의(P<0.05)。여대조조비교，치료조적총유효솔승고，차이유통계학의의(P<0.05)。결론 UDCA연합인치황구복액능강저혈청담홍소급내원성담즙산수평，가촉진담홍소、TBA배설，구유명현적리담、퇴황적료효。
Objective To investigate the curative ef ect of ursodeoxycholic acid (UDCA) combing with Yinzhihuang oral liquid in the treatment of infantile hepatitis syndrome (IHS). Method A total of 46 patinets with IHS were randomly divided into a treatment group of 26 cases (male 17 cases,female 9 cases;mean age 2.35 months) and the control group of 20 cases (male 10 cases,female 10 cases;mean age 2.05 months). Two groups were both treated with Compound Glycyrrhizin to reduce transaminase and basic treatment.The control group was only treated with Yinzhihuang oral liquid,treatment group was added UDCA 10 ~ 25 mg/(kg/d) basing on this, pointing 2 times to take ,continuous application of 14d for 1 course of treatment,part with 2 courses of treatment . Monitoring of the level of serum total bilirubin (TB), direct bilirubin (DB),alanine aminotransferase (ALT),gamma glutamyl transpeptidase (γ -GT) and total bile acid (TBA) of the two groups. Result Compared with prior treatment,the level of TB,DB,ALT,γ-GT and TBA were both dramatic decline of post reatment,the dif erence was statistical y significant (P<0.01). After treatment, the serum level of total bil irubin(TB),DB,γ-GT and TBA were significantly decreased,in the treatment group than the control group (P<0.05),the serum level of ALT was significant increased in the treatment group.t (P<0.05). Compared to two groups,the total ef ective rate of treatment group was bet er than that in control group,the dif erence was statistical y significant (P<0.05). Conclusion UDCA combined with Yinzhihuang oral liquid can reduce serum bilirubin and endogenous bile acid,also it can promote the excretion of bilirubin, TBA and the obvious cholagogic ef ect.
