CAJ | 학술논문

目的：探讨慢性乙型肝炎患者血清病毒含量与甲胎蛋白（ AFP）和a-L-岩藻糖苷酶（ AFU）组合检测临床应用的必要性。方法选择116例慢性乙型肝炎患者血清进行病毒含量（ HBV-DNA）、AFU与AFP浓度检测，根据病毒含量分组：HBV-DNA 1×103 copies/ml以下为阴性组；HBV-DNA 1×104～1×105 copies/ml为低病毒量组；HBV-DNA 1×106～1×108 copies/ml为高病毒量组，对每组组合检测结果进行分析。结果不同病毒含量组AFU、AFP浓度变化与正常对照组比较的差异则有统计学意义（P＜0．05）。 AFU与AFP的阳性比例随病毒复制量的增加而升高。结论慢性乙型肝炎患者，在定期进行病毒含量检测评估病毒的复制状况的同时，进行AFU和AFP水平组合检测发现肝组织的损害程度及演变过程，是必要的。
목적：탐토만성을형간염환자혈청병독함량여갑태단백（ AFP）화a-L-암조당감매（ AFU）조합검측림상응용적필요성。방법선택116례만성을형간염환자혈청진행병독함량（ HBV-DNA）、AFU여AFP농도검측，근거병독함량분조：HBV-DNA 1×103 copies/ml이하위음성조；HBV-DNA 1×104～1×105 copies/ml위저병독량조；HBV-DNA 1×106～1×108 copies/ml위고병독량조，대매조조합검측결과진행분석。결과불동병독함량조AFU、AFP농도변화여정상대조조비교적차이칙유통계학의의（P＜0．05）。 AFU여AFP적양성비례수병독복제량적증가이승고。결론만성을형간염환자，재정기진행병독함량검측평고병독적복제상황적동시，진행AFU화AFP수평조합검측발현간조직적손해정도급연변과정，시필요적。
Objective To investigate the relation between HBV-DNA quantification and concentration variation of α-L-fu-cosidase(AFU)and alpha fetal protein (AFP).Methods The levels of AFU,AFP and HBV-DNA in the serum of 116 chron-ic hepatitis B patients were determined .The 116 chronic hepatitis B patients were divided into 3 groups based on the levels of HBV-DNA-a negative group (HBV-DNA<1 ×103 copies/ml), a low viral load group (HBV-DNA 1 ×104 ~1 ×105 cop-ies/ml) and a high viral load group (HBV-DNA 1 ×106 ~1 ×108 copies/ml).Results The levels of AFU and AFP in the low and high viral load groups were significantly different as compared with those of the normal control group (P<0.05).The positive rates of AFU and AFP increased along with the increase of virus replication .Conclusion HBV-DNA in the HBV car-riers should be determined at regular intervals ,the replication of HBV-DNA be assessed and the levels of AFU and AFP be simultaneously detected to diagnose the early liver lesions for early treatment .