淮海医药
淮海醫藥
회해의약
JOURNAL OF HUAIHAI MEDICINE
2014年
2期
118-119
,共2页
痢疾志贺菌%种群%血清型%耐药性分析
痢疾誌賀菌%種群%血清型%耐藥性分析
이질지하균%충군%혈청형%내약성분석
Shigella dysenteriae%Species%Serotype%Drug resistance analysis
目的：了解本地区细菌性痢疾杆菌种群、血清型分布，并对菌株进行耐药分析，为细菌性痢疾的预防和临床治疗提供指导。方法对2008年5月～2012年12月期间我院感染病科300例确诊细菌性痢疾病例培养的菌株以及药敏试验结果进行回顾性分析。结果300例确诊病例中，男189例；女111例。检测出3个痢疾杆菌种群：福氏志贺菌（B群）290株，宋内氏志贺菌（C群）9株，痢疾志贺菌（ A群）1株，分别占96．68％、3．00％和0．33％。福氏志贺菌为优势菌株。检测出福氏痢疾杆菌6个血清型以及7个血清亚型。6个血清型主要为X型变种，其次为II型．其中137例患者进行了药物敏感试验，常见药物的耐药情况：氨苄青霉素耐药率100％，复方新诺明耐药率98．44％，诺氟沙星51．79％，主要敏感抗生素：头孢曲松钠95．59％，头孢哌酮钠89．71％。结论淮北地区3种痢疾杆菌株流行，以福氏痢疾杆菌为优势株，其中福氏痢疾杆菌血清型以X型为主，其次为II型。志贺氏菌对各种抗生素均有不同程度耐药，其中氨苄青霉素和复方新诺明最为严重，第三代头孢菌素敏感性较高。
目的：瞭解本地區細菌性痢疾桿菌種群、血清型分佈，併對菌株進行耐藥分析，為細菌性痢疾的預防和臨床治療提供指導。方法對2008年5月～2012年12月期間我院感染病科300例確診細菌性痢疾病例培養的菌株以及藥敏試驗結果進行迴顧性分析。結果300例確診病例中，男189例；女111例。檢測齣3箇痢疾桿菌種群：福氏誌賀菌（B群）290株，宋內氏誌賀菌（C群）9株，痢疾誌賀菌（ A群）1株，分彆佔96．68％、3．00％和0．33％。福氏誌賀菌為優勢菌株。檢測齣福氏痢疾桿菌6箇血清型以及7箇血清亞型。6箇血清型主要為X型變種，其次為II型．其中137例患者進行瞭藥物敏感試驗，常見藥物的耐藥情況：氨芐青黴素耐藥率100％，複方新諾明耐藥率98．44％，諾氟沙星51．79％，主要敏感抗生素：頭孢麯鬆鈉95．59％，頭孢哌酮鈉89．71％。結論淮北地區3種痢疾桿菌株流行，以福氏痢疾桿菌為優勢株，其中福氏痢疾桿菌血清型以X型為主，其次為II型。誌賀氏菌對各種抗生素均有不同程度耐藥，其中氨芐青黴素和複方新諾明最為嚴重，第三代頭孢菌素敏感性較高。
목적：료해본지구세균성이질간균충군、혈청형분포，병대균주진행내약분석，위세균성이질적예방화림상치료제공지도。방법대2008년5월～2012년12월기간아원감염병과300례학진세균성이질병례배양적균주이급약민시험결과진행회고성분석。결과300례학진병례중，남189례；녀111례。검측출3개이질간균충군：복씨지하균（B군）290주，송내씨지하균（C군）9주，이질지하균（ A군）1주，분별점96．68％、3．00％화0．33％。복씨지하균위우세균주。검측출복씨이질간균6개혈청형이급7개혈청아형。6개혈청형주요위X형변충，기차위II형．기중137례환자진행료약물민감시험，상견약물적내약정황：안변청매소내약솔100％，복방신낙명내약솔98．44％，낙불사성51．79％，주요민감항생소：두포곡송납95．59％，두포고동납89．71％。결론회북지구3충이질간균주류행，이복씨이질간균위우세주，기중복씨이질간균혈청형이X형위주，기차위II형。지하씨균대각충항생소균유불동정도내약，기중안변청매소화복방신낙명최위엄중，제삼대두포균소민감성교고。
Objective To determine characteristics and attribution of dysentery bacillus species and serotypes and analyze its drug resistance situation in patients with bacillary dysentery in Huaibei city so as to provide evidence for prevention , control and clinical treatment of shigellosis .Methods Strains were isolated from stool samples of 300 patients who were identified as sufferers of bacillary dysentery in Department of Infectious Diseases of Suixi County People 's Hospital from May 2008 to De-cember 2012 and drug susceptibilities test was retrospectively analyzed .Results 300 strains of shigella were isolated from pa-tients including 189 males and 111 females,among which 290 (96.68%) strains were S.flexneri,9(3.00%) strains were S. sonnei and 1(0.33%) strain was S.dysenteriae.S.flexneri was the dominant group .6 serotypes and 7 subtypes of S.flexneri were detected ,with serotype X of S .flexneri being the dominant serotype , followed by serotype II .The general resistant rate of shigella was highest to ampicillin (100%), followed by co-trimoxazole(98.44%),and norfloxacin (51.79%).The main sus-ceptibility rate was concerned with ceftriaxone (95.59%),and cefoperazone(89.71%).Conclusion The predominant spe-cies of bacillary dysentery is S .flexnei,followed by S.sonnei.Serotype X of S.flexnei is the dominant serotype in our region , followed by serotype II .S.sonnei is drug resistant to antibiotics to different extent ,the highest including ampicillin and co-tri-moxazole .The relative higher susceptibility is found in cephalosporin of the third generation .
