CAJ | 학술논문

以壳聚糖为原料制备N-甲基-N,N-双十二烷基壳聚糖盐酸盐（TMC），用FT-IR、EA对产物进行表征，溶解性实验表明TMC溶于乙醇等有机溶剂。采用乙醇注射法制备TMC囊泡，研究不同pH值介质中制得的载亲/疏水药物TMC囊泡的Zeta电位、粒径大小及分布、储存稳定性、载药及释放性能。结果表明，制得的TMC自组装囊泡Zeta电位为39.5～46 mV，粒径为50～100 nm，多分散系数为0.17～0.26，静置30天后仍保持稳定。Langmuir膜行为表明在较低pH值下TMC更易自组装，制备介质pH值不同对囊泡的粒径、药物释放行为影响较大，而释药环境pH值对囊泡的药物释放行为影响较小。
이각취당위원료제비N-갑기-N,N-쌍십이완기각취당염산염（TMC），용FT-IR、EA대산물진행표정，용해성실험표명TMC용우을순등유궤용제。채용을순주사법제비TMC낭포，연구불동pH치개질중제득적재친/소수약물TMC낭포적Zeta전위、립경대소급분포、저존은정성、재약급석방성능。결과표명，제득적TMC자조장낭포Zeta전위위39.5～46 mV，립경위50～100 nm，다분산계수위0.17～0.26，정치30천후잉보지은정。Langmuir막행위표명재교저pH치하TMC경역자조장，제비개질pH치불동대낭포적립경、약물석방행위영향교대，이석약배경pH치대낭포적약물석방행위영향교소。
N-methyl-N,N-didodecyl chitosan (TMC) was synthesized. The obtained chitosan derivative was characterized by FTIR , EA and solubility method. N-methyl-N,N-didodecyl chitosan self-assembled vesicles were prepared by the ethanol injection method. Zeta potential of the vesicles ranged from 39.5 mV to 49.5 mV,particle diameter ranged from 50 nm to 100 nm,diameter distribution ranged from 0.17 to 0.26,and the vesicles were very stable for a period of 30 days. The Langmuir behavior of TMC indicated that the lower the pH,the easier the self-assembly. Different pH values of preparation medium had a large effect on the particle size and drug release behavior of the vesicles. However,different pH values of release medium had little effect on the drug release behavior.