国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
2期
168-169
,共2页
角蛋白质类%抗环瓜氨酸肽抗体%关节炎,类风湿
角蛋白質類%抗環瓜氨痠肽抗體%關節炎,類風濕
각단백질류%항배과안산태항체%관절염,류풍습
keratins%anti-cyclic citrullinated peptide antibody%arthritis,rheumatoid
目的：探讨抗角蛋白抗体（anti-keratin antibodies，AKA）和抗环瓜氨酸肽（anti-cyclic citrullinated peptide，CCP）抗体检测对类风湿关节炎（rheumatoid arthritis，RA）诊断的指导意义。方法回顾性分析2012年7月至2013年5月间在该院就诊的1209例患者的血清AKA和抗CCP抗体的检测结果，其中类风湿关节炎患者241例，其他患者968例，所有血清以间接免疫荧光法检测AKA，酶联免疫法检测抗 CCP 抗体。结果在类风湿关节炎患者中，AKA 和抗 CCP 抗体的阳性率分别为49．79％和68．46％，在非类风湿关节炎的患者中的阳性率分别为2．69％和2．79％，差异均有统计学意义（犘＜0．01）；AKA 的特异性为97．31％，抗CCP抗体的特异性为97．21％。结论 AKA和抗CCP抗体的检测具有较高的特异性，对类风湿关节炎的辅助诊断具有重要意义。
目的：探討抗角蛋白抗體（anti-keratin antibodies，AKA）和抗環瓜氨痠肽（anti-cyclic citrullinated peptide，CCP）抗體檢測對類風濕關節炎（rheumatoid arthritis，RA）診斷的指導意義。方法迴顧性分析2012年7月至2013年5月間在該院就診的1209例患者的血清AKA和抗CCP抗體的檢測結果，其中類風濕關節炎患者241例，其他患者968例，所有血清以間接免疫熒光法檢測AKA，酶聯免疫法檢測抗 CCP 抗體。結果在類風濕關節炎患者中，AKA 和抗 CCP 抗體的暘性率分彆為49．79％和68．46％，在非類風濕關節炎的患者中的暘性率分彆為2．69％和2．79％，差異均有統計學意義（犘＜0．01）；AKA 的特異性為97．31％，抗CCP抗體的特異性為97．21％。結論 AKA和抗CCP抗體的檢測具有較高的特異性，對類風濕關節炎的輔助診斷具有重要意義。
목적：탐토항각단백항체（anti-keratin antibodies，AKA）화항배과안산태（anti-cyclic citrullinated peptide，CCP）항체검측대류풍습관절염（rheumatoid arthritis，RA）진단적지도의의。방법회고성분석2012년7월지2013년5월간재해원취진적1209례환자적혈청AKA화항CCP항체적검측결과，기중류풍습관절염환자241례，기타환자968례，소유혈청이간접면역형광법검측AKA，매련면역법검측항 CCP 항체。결과재류풍습관절염환자중，AKA 화항 CCP 항체적양성솔분별위49．79％화68．46％，재비류풍습관절염적환자중적양성솔분별위2．69％화2．79％，차이균유통계학의의（마＜0．01）；AKA 적특이성위97．31％，항CCP항체적특이성위97．21％。결론 AKA화항CCP항체적검측구유교고적특이성，대류풍습관절염적보조진단구유중요의의。
Objective To investigate the significance of anti-keratin antibodies (AKA)and anti-cyclic citrullinated peptide (CCP)antibodies for the clinical diagnosis of rheumatoid arthritis(RA).Methods Retrospective analysis of 1 209 cases from July 2012 to May 2013 in our hospital received serum AKA and CCP tests was done,of which 241 cases with rheumatoid arthritis and 968 cases with other patients.All patients serum AKA was detected by indirect immunofluorescence assay,and enzyme-linked im-munosorbent was used to assay anti-CCP.Results In patients with rheumatoid arthritis,AKA and CCP-positive rates were 49.79%and 68.46%,respectively,and in the non-RA patients,the positive rates were 2.69%and 2.79%,respectively.The RA and non-RA groups were compared,and the difference was statistically significant.AKA specificity was 97.31%,and anti-CCP specificity was 97.21%.Conclusion AKA and CCP detection have high specificity,which are useful markers for diagnosing and screening of rheu-matoid arthritis.
