CAJ | 학술논문

目的：探讨2型糖尿病合并脑梗死的相关危险因素。方法检测105例2型糖尿病患者（A组：2型糖尿病合并脑梗死患者45例；B组：单纯2型糖尿病患者60例）和40例健康人（C组：健康对照组）的三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白（HbA1c）、C反应蛋白（CRP）、D二聚体（D-dimer）水平。通过多元回归分析将各组患者既往史、实验室检测指标等各项临床资料进行统计学分析，以筛选2型糖尿病合并脑梗死的危险因素。结果A、B组高血压病史比例明显高于C组，差异均有统计学意义（P＜0．05）；A组患者重度颈动脉狭窄率明显高于B、C组，B组患者重度颈动脉狭窄率明显高于C组，差异均有统计学意义（P＜0．05）；A组患者TG、TC、HDL-C、LDL-C、HbA1c、CRP、D-dimer水平与B、C组比较差异有统计学意义（P＜0．05）。结论高血压病史、重度颈动脉狭窄率、TG、TC、LDL-C、HbA1c、CRP、D-dimer为2型糖尿病合并脑梗死的独立危险因素，而HDL-C为保护性因素。
목적：탐토2형당뇨병합병뇌경사적상관위험인소。방법검측105례2형당뇨병환자（A조：2형당뇨병합병뇌경사환자45례；B조：단순2형당뇨병환자60례）화40례건강인（C조：건강대조조）적삼선감유（TG）、총담고순（TC）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）、당화혈홍단백（HbA1c）、C반응단백（CRP）、D이취체（D-dimer）수평。통과다원회귀분석장각조환자기왕사、실험실검측지표등각항림상자료진행통계학분석，이사선2형당뇨병합병뇌경사적위험인소。결과A、B조고혈압병사비례명현고우C조，차이균유통계학의의（P＜0．05）；A조환자중도경동맥협착솔명현고우B、C조，B조환자중도경동맥협착솔명현고우C조，차이균유통계학의의（P＜0．05）；A조환자TG、TC、HDL-C、LDL-C、HbA1c、CRP、D-dimer수평여B、C조비교차이유통계학의의（P＜0．05）。결론고혈압병사、중도경동맥협착솔、TG、TC、LDL-C、HbA1c、CRP、D-dimer위2형당뇨병합병뇌경사적독립위험인소，이HDL-C위보호성인소。
Objective To explore the related risk factors for type 2 diabetes mellitus combined with cerebral infarction.Methods105 cases of patients with type 2 diabetes (Group A:45 patients with cerebral infarction,Group B:60 patients without cerebral infarction)and Group C:40 cases of healthy control were selected.TG,TC,HDL-C,LDL-C,HbA1c,CRP and D-dimer level were detected.Through the multiple regression analysis groups of patients with past medical history,laboratory examination indexes,the clinical statistical data was analyzed to screen the risk factors of type 2 diabetes mellitus and cerebral infarction.Results Group A, group B with history of hypertension was notably higher than that of group C,and difference had statistical significance (P<0.05). The rate of severe carotid stenosis in group A was significantly higher than that off and group B.The rate of severe carotid stenosis in group B was significantly higher than that of group C,and the difference had statistical significance (P<0.05).Group A pa-tients′serum TG,TC,HDL-C,LDL-C,HbA1c,CRP,and D-dimer compared with group B and group C,the difference was statisti-cally significant (P<0.05).Conclusion History of high blood pressure,rate of severe carotid stenosis,TG,TC,LDL-C,HbA1c,CRP and D-dimer are independent risk factors for type 2 diabetes combined with cerebral infarction,and HDL-C is protective factor.