中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
3期
9-10
,共2页
子宫内膜癌%IMP3%免疫组织化学
子宮內膜癌%IMP3%免疫組織化學
자궁내막암%IMP3%면역조직화학
Endometrial carcinoma%IMP3%Immunohistochemistry
目的：探讨胰岛素样生长因子ⅡmRNA结合蛋白3(insulin-like growth factorⅡmRNA binding protein3, IMP3)在子宫内膜癌中的表达及意义。方法选取子宫内膜癌70例,包括子宫内膜样癌52例及子宫浆液性腺癌18例,采用免疫组化Envision法检测IMP3的表达,同时对不同组织学类型及分级的肿瘤中IMP3的表达进行比较。结果 IMP3的++以上表达率在子宫内膜样癌与浆液性腺癌中分别为17.3%与88.9%,差异有统计学意义(P<0.01)；在高、中、低分化子宫内膜癌中的表达率分别为16.1%、31.8%及70.5%,高中分化组与低分化组相比差异有统计学意义(P<0.05)。结论 IMP3在子宫内膜癌中的过度表达主要出现在浆液性腺癌中,并与肿瘤的恶性生物学行为相关。IMP3检测有助于子宫内膜癌的鉴别诊断及预后评估。
目的：探討胰島素樣生長因子ⅡmRNA結閤蛋白3(insulin-like growth factorⅡmRNA binding protein3, IMP3)在子宮內膜癌中的錶達及意義。方法選取子宮內膜癌70例,包括子宮內膜樣癌52例及子宮漿液性腺癌18例,採用免疫組化Envision法檢測IMP3的錶達,同時對不同組織學類型及分級的腫瘤中IMP3的錶達進行比較。結果 IMP3的++以上錶達率在子宮內膜樣癌與漿液性腺癌中分彆為17.3%與88.9%,差異有統計學意義(P<0.01)；在高、中、低分化子宮內膜癌中的錶達率分彆為16.1%、31.8%及70.5%,高中分化組與低分化組相比差異有統計學意義(P<0.05)。結論 IMP3在子宮內膜癌中的過度錶達主要齣現在漿液性腺癌中,併與腫瘤的噁性生物學行為相關。IMP3檢測有助于子宮內膜癌的鑒彆診斷及預後評估。
목적：탐토이도소양생장인자ⅡmRNA결합단백3(insulin-like growth factorⅡmRNA binding protein3, IMP3)재자궁내막암중적표체급의의。방법선취자궁내막암70례,포괄자궁내막양암52례급자궁장액성선암18례,채용면역조화Envision법검측IMP3적표체,동시대불동조직학류형급분급적종류중IMP3적표체진행비교。결과 IMP3적++이상표체솔재자궁내막양암여장액성선암중분별위17.3%여88.9%,차이유통계학의의(P<0.01)；재고、중、저분화자궁내막암중적표체솔분별위16.1%、31.8%급70.5%,고중분화조여저분화조상비차이유통계학의의(P<0.05)。결론 IMP3재자궁내막암중적과도표체주요출현재장액성선암중,병여종류적악성생물학행위상관。IMP3검측유조우자궁내막암적감별진단급예후평고。
Objective The expression of insulin-like growth factor Ⅱ mRNA binding protein3(IMP3) in endometrial carcinomas was detected to explore it’s significance in development of tumor, differential diagnosis and prognosis. Methods 70 endometrial carcinomas including 52 endometrioid carcinomas and 18 serous carcinomas were selected and expression of IMP3 was detected by using immunohistochemistry Envision method. The positive rates were compared respectively in different histological type and grade. Results IMP3 located mainly in the cytoplasm of tumor cells and the positive rate above 50%was set as the dividing value. Statistics showed that the positive expression rate of IMP3 in endometrioid carcinomas and serous carcinomas was 17.3%and 88.9%respectively, there was a significant difference between two groups(P<0.01).IMP3 expressed 16.1%,31.8%,70.5%positively in well, moderate, and poor-differentiated EC respectively, it showed significant difference between moderate group and poor group(P<0.05). Conclusion IMP3 plays an important role in the development of EC and expresses excessively in serous carcinoma specifically. Its expression rate shows closely correlation with the malignant biological characteristics thus to be a valuable indicator for differential diagnosis and prognosis evaluation of EC.
